Calcium Pyrophosphate
Calcium Pyrophosphate is the inorganic calcium salt of pyrophosphoric acid, with the formula Ca₂P₂O₇ (CAS 7790-76-3). It is a white, odourless, insoluble mineral powder produced by the controlled thermal condensation of calcium phosphate.
The compound is best known as a polishing abrasive in toothpaste formulations, where it removes plaque and surface stains without unacceptably damaging tooth enamel. It is also used as a food-grade calcium source and as a flow agent in selected food and pharmaceutical applications.
We source bulk Calcium Pyrophosphate from top China manufacturers for our partners, working with several of them. The manufacturers are in Jiangsu and Guangxi. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
Grades / Types Available: Food Grade, FCC, E 450(vii)
| Item | Specification |
|---|---|
| Appearance | White fine crystalline powder, odorless, tasteless |
| Assay (Ca₂P₂O₇) | ≥ 96.0% |
| P₂O₅ Content | ≥ 54.0% |
| CaO Content | 43.0–45.0% |
| Loss on Ignition | ≤ 2.0% |
| pH (10% slurry) | 6.0–8.0 |
| Fluoride (F) | ≤ 50 mg/kg |
| Particle Size | ≥ 95% through 100 mesh |
| Water-Soluble Matter | ≤ 1.0% |
| Heavy Metals (as Pb) | ≤ 10 mg/kg |
| Lead (as Pb) | ≤ 2 mg/kg |
| Arsenic (as As) | ≤ 3 mg/kg |
| Content (P2O5) % (FCC) | 61.0-66.0 |
| Arsenic ≤ (Food Grade) | 3.0 mg/kg |
| Lead ≤ (Food Grade) | 2.0 mg/kg |
| Fluoride ≤ (Food Grade) | 30.0 mg/kg (as F) |
| Loss on ignition % (Food Grade) | ≤10.0 |
| Acid-insoluble matter ≤ (FCC) | 0.4% |
| Cadmium ≤ (FCC) | 1 mg/kg |
| Mercury ≤ (FCC) | 1 mg/kg |
| Aluminium ≤ (FCC) | 200 mg/kg |
Common Markets Grades
Calcium Pyrophosphate is differentiated by particle morphology, particle-size distribution, and abrasivity index.
Dental-grade material is the largest segment, with a tightly controlled median particle size of around 5 to 15 microns and a defined Radioactive Dentine Abrasion (RDA) range to balance cleaning efficacy with low enamel wear. Toothpaste manufacturers buy it in food-grade or pharmaceutical-grade qualifications, often blended with hydrated silica and calcium carbonate.
Food Chemicals Codex grade is used as a calcium source and anticaking agent in selected food applications. It must meet strict limits on fluoride, heavy metals, and acid-insoluble residue.
Two crystalline polymorphs (α- and β-Ca₂P₂O₇) are produced depending on the calcination temperature, with β-Ca₂P₂O₇ being the most common commercial form.
Applications
- Polishing abrasive in fluoride toothpaste, sensitive toothpaste, and tartar-control formulations
- Calcium source in chewable supplements and powdered nutritional products
- Food additive functioning as buffer, sequestrant, and stabiliser
- Anticaking and flow aid in powdered seasonings and dry blends
- Calcium and phosphorus enrichment of poultry, swine, and aquaculture feeds
- Component of dental prophylaxis pastes used in clinical hygiene cleaning
- Reference material in biomineralization and bone-cement research
- Bioceramic ingredient in degradable orthopedic and dental implants
- Acid-acceptor and stabiliser in PVC polymer formulations
- Mild abrasive in metal and jewelry polishing compounds
- Pharmaceutical excipient in selected tablet and powder formulations
Brands Using Calcium Pyrophosphate
Widely-distributed consumer products that list Calcium Pyrophosphate on the ingredient label.
- Colgate-Palmolive (Colgate)Colgate Total Active Prevention Original Toothpaste ↗Colgate Total Original toothpaste ingredient list: 'Glycerin, Aqua, Hydrated Silica, Sorbitol, Calcium Pyrophosphate, Aroma, Sodium Lauryl Sulfate, Tetrasodium Pyrophosphate, Cellulose Gum, Potassium Nitrate, Stannous Fluoride, Xanthan Gum, Sodium Saccharin.' Calcium pyrophosphate functions as an abrasive/polishing agent.Label verified 2026-05-24
- Colgate-Palmolive (Colgate)Colgate Total Active Prevention + Gum Care & Sensitivity Toothpaste ↗Fluoride toothpaste for gum care and sensitivity whose ingredient list on the brand page reads 'Glycerin, Aqua, Hydrated Silica, Sorbitol, Calcium Pyrophosphate, Sodium Methyl Cocoyl Taurate, Tetrasodium Pyrophosphate, ...', with calcium pyrophosphate acting as the cleaning and polishing abrasive.Label verified 2026-09-01
- Procter & Gamble (Crest)Crest 3D White Brilliance Pro Ultra White Toothpaste ↗Crest 3D White Brilliance Pro Ultra White panel (per manufacturer/EWG SkinDeep verified listing) lists calcium pyrophosphate among the inactive abrasive/polishing ingredients, alongside hydrated silica and sodium hexametaphosphate.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Calcium Pyrophosphate
Top Calcium Pyrophosphate manufacturers in China.
Gangxi Yunbo Health Technology Co., Ltd.10 ingredients in the directory
Lianyungang Dongtai Food Ingredients Co., Ltd.11 ingredients in the directory
Lianyungang Zhonghong Chemical Co., Ltd.11 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Calcium Pyrophosphate
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Calcium Pyrophosphate out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Calcium Pyrophosphate together with other ingredients such as Sodium Acetate, Calcium Citrate and Sodium Lactate into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Calcium Pyrophosphate is approved as a food additive and dental-care ingredient in essentially all regulated markets.
In the European Union, Regulation (EC) 1333/2008 lists it as part of the calcium phosphates group (E450 family) and permits it as an emulsifier, sequestrant, and stabiliser. The U.S. Food and Drug Administration affirms it as GRAS under 21 CFR 182.8223 for direct food use as a nutrient supplement.
In dentifrice applications it is recognised under the FDA OTC monograph for anticaries products and is included in pharmacopoeial monographs for dental abrasives. Cosmetic and personal care use is covered by the relevant INCI listing as Tetracalcium Diphosphate.
Pharmacopoeial monographs appear in USP-NF and Ph. Eur. for selected pharmaceutical and dental applications.
Manufacturing Process
Calcium Pyrophosphate is produced by the thermal condensation of calcium phosphate precursors.
The most common route starts from dicalcium phosphate dihydrate (CaHPO₄·2H₂O). The starting material is calcined at 400 to 900 °C, driving off water and dehydrating two adjacent orthophosphate groups into a pyrophosphate linkage. The β-polymorph forms below about 750 °C and converts to the α-polymorph at higher temperatures.
The calcined product is cooled, milled, and air-classified to the target particle-size distribution. Dental-grade material undergoes additional jet milling and tight control of d10, d50, and d90 values to deliver consistent cleaning performance.
Food-grade and pharmaceutical-grade material is produced under cGMP conditions, with controls on fluoride and heavy-metal carryover from the phosphate feedstock and on residual orthophosphate from incomplete condensation.
