Collagen Type-Ii
Collagen Type II is the dominant structural protein of hyaline cartilage and is produced commercially from chicken sternum cartilage and, less often, from bovine tracheal cartilage. It is produced either as undenatured native Type II collagen (UC-II style) at low daily doses or as a hydrolysed Type II peptide for joint-positioned formulas.
The native form preserves the triple helix and characteristic epitopes recognised by the gut-associated immune system, while the hydrolysed form provides the amino acids typical of Type II, including glycine, proline, hydroxyproline, and Type II-specific hydroxylysine glycosides.
We source bulk Collagen Type-Ii from top China manufacturers for our partners. The manufacturers are in Beijing and Shandong. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
Grades / Types Available: Food Grade, Pharmaceutical Grade
| Item | Specification |
|---|---|
| Appearance | White to off-white fine powder |
| Protein (dry basis, N×5.55) | ≥85% |
| Type II Collagen Content | ≥25% |
| Chondroitin Sulfate (natural) | 5–20% |
| Moisture | ≤8.0% |
| Ash | ≤5.0% |
| pH (1% sol.) | 5.0–7.0 |
| Solubility | Grade-dependent |
| Heavy Metals (as Pb) | ≤1 mg/kg |
| Total Plate Count | ≤10,000 cfu/g |
| Salmonella | Absent in 25g |
| Purity | > 90% (Food Grade) |
| Moisture/Loss on Drying | < 10% (Food Grade) |
| Lead | < 1 ppm |
| Arsenic | < 0.5 ppm |
| Yeast & Mold | < 100 cfu/g |
Common Markets Grades
Collagen Type II is graded by form, source, and active-content specification.
Native undenatured grades are standardised to total Type II collagen content, typically 20 to 25 percent in the finished concentrate, with a target oral dose around 40 milligrams per day. Process control protects the triple-helix structure through low-temperature handling and gentle pepsin digestion.
Hydrolysed grades carry high protein content with defined molecular weight, usually in the 2 to 5 kDa range, and much higher daily doses in the multi-gram range.
Source streams include chicken sternum cartilage, which is the main raw material, and bovine tracheal cartilage for kosher and halal-positioned segments where chicken sourcing is not acceptable. Both formats are typically packed in foil-lined sacks with controlled humidity.
Applications
- Joint-health capsules and tablets positioned around mobility, comfort, and flexibility
- Stand-alone single-active joint products at low daily doses (native form)
- Combination joint blends with glucosamine, chondroitin, MSM, or boswellia
- Sports-nutrition joint-support formulas for runners and weight-trained athletes
- Functional gummies and chewables in mobility-positioned ranges
- Veterinary supplements for canine and equine joint support
- Powdered drink mixes for joint and active-aging positioning
- Beauty-and-joint dual-claim products combined with Type I peptide
- Clinical nutrition products for osteoarthritis support
- Medical foods and meal replacements in elderly nutrition
- Pet treats and chews aimed at joint health
Brands Using Collagen Type-Ii
Widely-distributed consumer products that list Collagen Type-Ii on the ingredient label.
- Doctor's BestGlucosamine Chondroitin MSM + UC-II ↗Combines glucosamine, chondroitin and MSM with 40 mg UC-II undenatured type II collagen in a 90-capsule joint formula.Label verified 2026-05-24
- Doctor's BestBoswellia with UC-II ↗Doctor's Best Boswellia with UC-II pairs Boswellia serrata extract with UC-II undenatured Type II collagen in a 60-capsule joint-comfort formula focused on glycosaminoglycan support and joint lubrication.Label verified 2026-05-24
- SolgarSolgar No. 7 Vegetable Capsules ↗Solgar No. 7 features UC-II Standardized Cartilage (undenatured Type II collagen, Lonza trademark) alongside botanicals; the product page positions it for joint flexibility, mobility and comfort within 5 days.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Collagen Type-Ii
Top Collagen Type-Ii manufacturers in China.
Beijing Semnl Biotechnology Co., Ltd.10 ingredients in the directory
Dezhou Lanli Biotechnology Co., Ltd.10 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Collagen Type-Ii
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Collagen Type-Ii out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Collagen Type-Ii together with other ingredients such as Collagen Peptide, Soy Protein Isolate and Fish Collagen Peptide into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Collagen Type II is regulated as a dietary supplement ingredient and as a food ingredient in major markets.
In the United States native undenatured Type II collagen has been the subject of New Dietary Ingredient notifications and is marketed under a self-affirmed generally recognized as safe position by some suppliers. The U.S. Food and Drug Administration permits its use in dietary supplements at labelled doses.
In the European Union general food law covers it, together with the Regulation EC 853/2004 hygiene rules for collagen of animal origin. Some Member States treat low-dose native Type II material as a borderline case between food supplement and medicinal product, requiring careful claim management.
Halal certification is available for poultry-derived material from approved slaughter, and kosher certification is rare because of the difficulty of qualifying poultry cartilage supply.
Manufacturing Process
Production starts with chicken sternum cartilage recovered from slaughter operations. The cartilage is washed, trimmed of meat residues, and ground to a uniform particle size.
For native undenatured material, ground cartilage is subjected to a low-temperature pepsin digestion that releases the triple helix while preserving its conformation. The extract is filtered, concentrated by low-temperature ultrafiltration, and freeze-dried or low-temperature spray-dried to keep the epitopes intact.
For hydrolysed Type II, the cartilage is heat-extracted to release Type II gelatin, then hydrolysed with food-grade alkaline or neutral bacterial proteases. The peptide solution is decolorised, deionized, ultrafiltered, concentrated, and spray-dried by conventional means.
Quality release for native material includes a circular-dichroism or ELISA-based assay to confirm triple-helix retention, while hydrolysed material is checked against molecular-weight distribution and protein content.
