Undenatured Type Ii Collagen
Undenatured Type II Collagen is a native, triple-helix collagen fraction sourced from chicken sternal cartilage and used at low milligram doses for joint-health applications.
The most widely recognised commercial form is UC-II, a glycosylated type II collagen processed under non-hydrolytic, low-temperature conditions so the molecule arrives in the gut with its native conformation intact. This intact epitope is what distinguishes it from hydrolysed collagen peptides.
We source bulk Undenatured Type Ii Collagen from top China manufacturers for our partners, working with several of them. The manufacturers are in Zhejiang, Beijing and Hubei. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
Grades / Types Available: Food Grade, Pharmaceutical Grade
| Item | Specification |
|---|---|
| Appearance | White to off-white fine powder |
| Protein (dry basis, N×5.55) | ≥60% |
| Undenatured Type II Collagen | ≥25% |
| Glycosaminoglycans | Present |
| Moisture | ≤8.0% |
| Ash | ≤5.0% |
| Processing | Low-temperature, non-denatured |
| Particle Size (80 mesh) | ≥95% |
| Heavy Metals (as Pb) | ≤1 mg/kg |
| Total Plate Count | ≤5,000 cfu/g |
| Salmonella | Absent in 25g |
| Purity (Food Grade) | > 90% |
| Moisture/Loss on Drying | < 10% |
| pH | 6.0 - 7.5 |
| Lead | < 1 ppm |
| Arsenic | < 0.5 ppm |
| Yeast & Mold | < 100 cfu/g |
Common Markets Grades
The standard commercial grade is a fine off-white powder standardised to 25 percent undenatured type II collagen by mass, with the balance composed of cartilage matrix proteins, glycosaminoglycans, and residual chondroitin.
A typical adult dose is 40 milligrams of standardised powder per day, delivering 10 milligrams of bioactive undenatured collagen. Capsule fills of 40 mg and 80 mg dominate the supplement market.
Premium grades carry batch-level certificates verifying triple-helix integrity by circular dichroism or ELISA against denatured-collagen controls. This testing is the only way to confirm the native conformation has survived processing.
Veterinary grades for canine and equine joint support carry similar potency but looser sieve and microbiological specifications.
Applications
- Daily joint-comfort supplements for osteoarthritis of the knee, hip, and hand
- Mobility and flexibility formulas for active adults and post-exercise recovery
- Combination products with glucosamine, chondroitin, MSM, or boswellia
- Once-daily small-capsule formats preferred by consumers who reject high-gram collagen scoops
- Sports-nutrition products targeting cartilage maintenance in runners and weight-bearing athletes
- Senior wellness multivitamins and joint-and-bone blends
- Veterinary chews and tablets for working dogs, agility dogs, and aging companion animals
- Equine joint pastes and top-dress powders for performance horses
- Clinical nutrition products positioned around oral tolerance and immunomodulation
- Functional food bars and gummies built around joint-health claims
Brands Using Undenatured Type Ii Collagen
Widely-distributed consumer products that list Undenatured Type Ii Collagen on the ingredient label.
- Doctor's BestBioAvailable Boswellia + UC-II ↗Doctor's Best pairs 500 mg of Boswellia serrata extract with 40 mg of patented UC-II undenatured type II collagen per two-capsule serving for joint comfort.Label verified 2026-05-24
- Doctor's BestGlucosamine Chondroitin MSM + UC-II ↗Joint formula combines glucosamine sulphate, chondroitin and MSM with 40 mg of UC-II undenatured type II collagen from chicken sternal cartilage.Label verified 2026-05-24
- Move FreeMove Free Ultra with UC-II Joint Health Tablets ↗Schiff Move Free Ultra delivers UC-II undenatured type II collagen plus hyaluronic acid in a one-tablet-per-day joint comfort supplement.Label verified 2026-05-24
- Move FreeMove Free Ultra Triple Action ↗A tablet pairing UC-II type II collagen with boron and hyaluronic acid.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Undenatured Type Ii Collagen
Top Undenatured Type Ii Collagen manufacturers in China.
Beijing Semnl Biotechnology Co., Ltd.10 ingredients in the directory
HS NUTRA Co., Ltd.7 ingredients in the directory
Hubei Huge Collagen Ii Biotechnology Co., Ltd.5 ingredients in the directory
Jiaxing Nudikon Lifescience Co., Ltd.4 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Undenatured Type Ii Collagen
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Undenatured Type Ii Collagen out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Undenatured Type Ii Collagen together with other ingredients such as Collagen Peptide, Soy Protein Isolate and Fish Collagen Peptide into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
In the United States undenatured type II collagen counts as a dietary ingredient, and the UC-II form holds self-affirmed GRAS status for use in conventional foods and beverages and is the subject of multiple New Dietary Ingredient notifications filed with FDA.
In the European Union it is marketed as a food supplement ingredient. The chicken-cartilage source falls under standard novel-food and allergen-labelling rules.
Health Canada has licensed finished products containing undenatured type II collagen under the Natural Health Products Directorate for joint-health indications.
The ingredient is not listed in pharmacopoeial monographs because it is sold as a nutritional ingredient rather than a pharmaceutical active. Allergen declaration for poultry is required in most markets.
Manufacturing Process
Manufacture begins with chicken sternal cartilage recovered from poultry processing. The cartilage is washed, trimmed, and ground while the temperature is held low enough to avoid thermal denaturation.
The ground material is then treated under proprietary non-hydrolytic conditions that solubilise matrix components without breaking the collagen triple helix. Acidic enzymatic steps are typically avoided because pepsin and pH extremes will unwind the helix.
After clarification, the liquid is concentrated and spray-dried under controlled inlet and outlet temperatures. Inlet temperatures are kept below the denaturation threshold for type II collagen, which sits near 37 to 40 degrees Celsius for the isolated molecule.
Final powder is blended to a target potency, sieved, and tested by ELISA or related immunoassay to confirm the percentage of collagen that remains in its native triple-helical form.
