CAS 50-14-6

Vitamin D2

Vitamin D2 is the plant and fungal form of the fat-soluble vitamin D family, used in supplement, pharmaceutical, food, and feed formulations as ergocalciferol.

The molecule carries the formula C₂₈H₄₄O, a molar mass of 396.65 g/mol, and the CAS number 50-14-6. Like vitamin D3 it is a secosteroid, generated by ultraviolet irradiation of a sterol precursor, in this case ergosterol from yeast cell walls or from mushroom tissue.

We source bulk Vitamin D2 from top China manufacturers for our partners, working with several of them. The manufacturers are in Zhejiang and Sichuan. A smaller requirement can ship in a combined container with other ingredients.

Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.

or call +86-21-6858 0751

Packaging: 190 kg steel drum or 25 kg jerrican

ISO 9001
HACCP
Halal
Kosher

Specifications

Item	Specification
Appearance	White to off-white crystalline powder or pale yellow oil
Potency (IU/g)	100,000 to 40,000,000 (grade dependent)
Specific rotation (crystalline)	+103° to +112°
Related substances	≤ 3.0%
Peroxide value	≤ 10 meq/kg
Heavy metals (as Pb)	≤ 10 mg/kg
Arsenic	≤ 3 mg/kg
Available forms	Crystalline, Oil, Powder

Common Markets Grades

Oil and dry formats of ergocalciferol cover a range of activity-keyed potencies.

Crystalline ergocalciferol at 40 million IU per gram is the reference active substance for pharmaceutical and high-potency supplement work. It is markedly oxygen and light sensitive and is normally handled under nitrogen blanket in amber containers.

Oil-resin grades at 1.0 to 4.0 million IU per gram, diluted in refined corn or medium-chain triglyceride oil, serve liquid drop, softgel, and oil-based pharmaceutical preparations.

Beadlet and cold-water-dispersible grades at 100 and 500 thousand IU per gram, built on modified starch or acacia gum matrices with antioxidant systems, are the standard supply for vegan-certified tablets, capsules, and beverage fortification. Pharmacopoeial grades meet USP and Ph. Eur. monographs.

Applications

Vegan-certified vitamin D supplements as drops, sprays, capsules, and chewables
Plant-based milk alternative fortification
Vegetarian and vegan multivitamin tablets and softgels
Pediatric drops and high-dose deficiency-treatment pharmaceuticals
Clinical and enteral nutrition products
UV-treated mushroom products and other functional food vehicles
Mandatory fortification of margarine and selected staple foods in some jurisdictions
Breakfast cereals and meal-replacement products with plant-positioning
Sports-nutrition and recovery formulations
Pharmaceutical preparations for rickets and osteomalacia
Animal feed premixes, particularly where plant sourcing is specified
Specialty pet diets and exotic-animal husbandry programs

Brands Using Vitamin D2

Widely-distributed consumer products that list Vitamin D2 on the ingredient label.

Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.

China Manufacturers of Vitamin D2

Top Vitamin D2 manufacturers in China.

Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.

How We Help Source Vitamin D2

Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Vitamin D2 out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Vitamin D2 together with other ingredients such as Vitamin C, Vitamin D3 and Vitamin E into one 20' FCL. If your quantity is small, we can also ship LCL.

Regulatory Status

Ergocalciferol is authorised as a nutrient and as a pharmaceutical active substance in essentially every regulated market.

The European Union lists it as a permitted vitamin source under Regulation (EC) No 1925/2006 and Directive 2002/46/EC. UV-treated mushrooms and UV-treated yeast carry separate novel-food authorisations for vitamin D2 fortification of bread, baking, and supplement matrices. EFSA has set a tolerable upper intake level of 100 µg per day for adults, shared with vitamin D3.

The U.S. Food and Drug Administration recognises ergocalciferol as GRAS for specific food categories and approves it as a prescription drug at high dose for the treatment of vitamin D deficiency. The Daily Value sits at 20 µg.

Codex Alimentarius includes it in the Advisory List of Nutrient Compounds. JECFA has reviewed both D2 and D3 and treats them as a group for safety assessment.

Pharmacopoeial monographs appear in the USP, Ph. Eur., JP, and BP. Vegan certification is straightforward because the upstream feedstock is yeast or mushroom rather than lanolin, and Halal and Kosher certifications are also routinely offered.

Manufacturing Process

Vitamin D2 Manufacturing Process

Loading process diagram…

Industrial ergocalciferol is produced from ergosterol, the principal sterol of fungal and yeast cell membranes.

The starting material is recovered from spent Saccharomyces cerevisiae biomass after brewery, baking, or dedicated fermentation operations. The yeast is autolysed, the lipid fraction is extracted with hydrocarbon solvent, and ergosterol is crystallised from the lipid concentrate to deliver high-purity provitamin material.

Photolysis is the defining step. A thin film of ergosterol in an inert solvent is irradiated with ultraviolet light at approximately 295 nm, opening the steroid B-ring to give previtamin D2. A thermal rearrangement at controlled temperature isomerises the previtamin to ergocalciferol.

The crude photoproduct is purified by chromatography and recrystallisation to deliver high-purity crystal, then dissolved in oil or formulated into beadlets for downstream supply. Production is concentrated in Europe and China. UV-treated mushrooms represent a parallel and smaller route in which whole-food matrices are exposed to UV light during post-harvest processing to generate vitamin D2 in situ.