CAS 67-97-0

Vitamin D3

Vitamin D3 is the animal-derived form of the fat-soluble vitamin D family, used in supplement, food, pharmaceutical, and feed formulations as cholecalciferol.

The molecule carries the formula C₂₇H₄₄O, a molar mass of 384.64 g/mol, and the CAS number 67-97-0. Activity is expressed in micrograms or international units, with 1 IU equal to 0.025 µg of cholecalciferol.

We source bulk Vitamin D3 from top China manufacturers for our partners, working with several of them. The manufacturers are in Zhejiang and Jiangxi. For this ingredient the minimum order is 500 kg and a 20-foot container takes 10 MT, and a smaller requirement can ship in a combined container with other ingredients.

Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.

or call +86-21-6858 0751

Minimum order: 500 kg
Qty in 20' FCL: 10 MT
Packaging: 190 kg steel drum or 25 kg jerrican

ISO 9001
HACCP
Halal
Kosher

Specifications

Item	Specification
Appearance	White crystalline powder, pale yellow oil, or yellow to brown CWS powder
Potency (IU/g)	100,000 to 40,000,000 (grade dependent)
Specific rotation (crystalline)	+105° to +112°
Related substances	≤ 3.0%
Peroxide value	≤ 10 meq/kg
Heavy metals (as Pb)	≤ 10 mg/kg
Arsenic	≤ 3 mg/kg
Loss on drying (CWS)	≤ 8.0%
Available forms	Resin, Oil, 100 CWS, 500 CWS, Crystal, Vegan D3

Common Markets Grades

Cholecalciferol divides into oil and dry formats, with potency keyed to formulation needs.

Crystalline cholecalciferol at 40 million IU per gram is the reference active substance for pharmaceutical and high-potency supplement work. It is highly oxygen-sensitive and is normally handled under nitrogen blanket.

Oil-resin grades at 1.0 to 4.0 million IU per gram, typically diluted in medium-chain triglyceride or refined corn oil, serve liquid drop, softgel, and oil-based pharmaceutical preparations.

Beadlet and cold-water-dispersible grades at 100, 200, 400, and 500 thousand IU per gram, built on gelatin or modified starch matrices with antioxidant systems, are the standard supply for tablets, sachets, beverage fortification, and animal-feed premixes. Pharmacopoeial grades meet USP and Ph. Eur. monographs.

Applications

Stand-alone vitamin D supplements as drops, sprays, capsules, and chewables
Multivitamin and bone-health combination products with calcium and vitamin K2
Fortification of fluid milk, plant-based milk alternatives, and yogurt
Margarine, edible oil, and breakfast cereal fortification programmes
Infant formula and follow-on formula at regulated levels
Pediatric and adult deficiency-treatment pharmaceuticals
Clinical and enteral nutrition products
Topical dermatology preparations for psoriasis and related disorders
Veterinary pharmaceuticals for calcium homeostasis disorders
Poultry feed premixes to prevent rickets and support eggshell quality
Aquaculture and companion-animal diets
Sports-nutrition products targeting performance and recovery

Brands Using Vitamin D3

Widely-distributed consumer products that list Vitamin D3 on the ingredient label.

Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.

China Manufacturers of Vitamin D3

Top Vitamin D3 manufacturers in China.

Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.

How We Help Source Vitamin D3

Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Vitamin D3 out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Vitamin D3 together with other ingredients such as Vitamin C, Vitamin E and Natural Vitamin E into one 20' FCL. If your quantity is small, we can also ship LCL.

Regulatory Status

Cholecalciferol is authorised as a nutrient and as a pharmaceutical active substance in every regulated market.

The European Union lists it as a permitted vitamin source under Regulation (EC) No 1925/2006 and Directive 2002/46/EC. EFSA has set a tolerable upper intake level of 100 µg per day for adults.

The U.S. Food and Drug Administration recognises cholecalciferol as GRAS under 21 CFR 184.1950 for specific food categories, with broader use permitted through food-additive petitions. The Daily Value sits at 20 µg.

Codex Alimentarius includes it in the Advisory List of Nutrient Compounds. JECFA has reviewed the substance for use in infant formula and follow-on formula.

Monographs appear in the USP, Ph. Eur., JP, and BP. Halal and Kosher certifications are routinely available; vegan certification requires a non-lanolin source.

Manufacturing Process

Vitamin D3 Manufacturing Process

Loading process diagram…

Industrial cholecalciferol is produced from 7-dehydrocholesterol, the same provitamin found in mammalian skin.

The starting material is isolated from lanolin, the waxy secretion of sheep wool, which is degreased, saponified, and subjected to multiple crystallisations to recover cholesterol. The cholesterol is then converted to 7-dehydrocholesterol via bromination and dehydrohalogenation.

Photolysis is the defining step. A thin film of 7-dehydrocholesterol in an inert solvent is irradiated with ultraviolet light at around 295 nm, opening the steroid B-ring to give previtamin D3. A thermal rearrangement at controlled temperature isomerises the previtamin to cholecalciferol.

The crude photoproduct is purified by chromatography and recrystallisation to deliver high-purity crystal, which is then dissolved in oil or formulated into beadlets for downstream supply. The principal manufacturers operate in Europe and China, with vegan alternatives derived from lichen biomass occupying a small but growing share.