L-Ornithine-L-Aspartate
L-Ornithine-L-Aspartate is a 1:1 salt of the non-proteinogenic amino acid L-ornithine with the dicarboxylic amino acid L-aspartic acid, sold as a white crystalline powder readily soluble in water.
The compound has the formula C₅H₁₂N₂O₂·C₄H₇NO₄, a molar mass of 265.27 g/mol, and CAS number 3230-94-2. It is widely known under the abbreviation LOLA and has a long clinical track record in the management of hyperammonemia and hepatic encephalopathy.
We source bulk L-Ornithine-L-Aspartate from top China manufacturers for our partners. The manufacturer is in Hebei. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
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- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
Grades / Types Available: Commercialized production
| Item | Specification |
|---|---|
| Appearance | White crystalline powder |
| Assay | ≥ 99.0% |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals (as Pb) | ≤ 10 mg/kg |
| pH (5% solution) | 4.5-6.5 |
| Purity/Assay | ≥ 98% |
| Moisture/Loss on Drying | ≤ 0.5% |
| Ash | ≤ 0.1% |
| Lead | ≤ 1 ppm |
| Arsenic | ≤ 0.5 ppm |
| Total Plate Count | ≤ 1000 cfu/g |
| Yeast & Mold | ≤ 100 cfu/g |
Common Markets Grades
L-Ornithine-L-Aspartate meets two specifications, pharmaceutical and nutraceutical, both at 98.5 percent minimum assay on the dry basis.
Pharmaceutical grade dominates volume. It is produced for the manufacture of intravenous infusion concentrates, oral granule sachets, and film-coated tablets used in clinical hepatology. The grade meets the major pharmacopoeial standards and carries tighter limits on heavy metals, residual solvents, and bacterial endotoxins.
Nutraceutical grade is produced for sports nutrition powders, fatigue-recovery formulas, and adjunctive liver-support supplement blends.
Both grades are typically delivered as a fine free-flowing powder packed in 5 or 25 kg fibre drums with low-density polyethylene liners. Custom granulations and direct-compression versions are made on order for solid-dose pharmaceutical lines.
Applications
- Intravenous infusion concentrates for acute hepatic encephalopathy management
- Oral granule sachets for chronic hyperammonemia in cirrhosis patients
- Film-coated tablets for outpatient liver disease therapy
- Adjunctive treatment in alcoholic and non-alcoholic fatty liver disease
- Sports nutrition powders for exercise-induced ammonia clearance support
- Endurance athlete recovery formulas marketed around fatigue reduction
- Liver-support nutraceutical blends with silymarin and choline
- Clinical nutrition formulas for cirrhotic patients requiring protein management
- Veterinary hepatic-support formulations in companion animal medicine
- Bodybuilding recovery supplements positioning around ammonia disposal
- Research reagent in ammonia metabolism and urea cycle studies
- Pharmaceutical compounding for individualized clinical preparations
Brands Using L-Ornithine-L-Aspartate
Widely-distributed consumer products that list L-Ornithine-L-Aspartate on the ingredient label.
- Hepa-Merz (Merz Therapeutics)Hepa-Merz Granules 3000 ↗Each sachet contains 3 g L-ornithine-L-aspartate (LOLA) for the treatment of hepatic encephalopathy and impaired ammonia detoxification in liver cirrhosis.Label verified 2026-05-24
- Hepa-Merz (Merz Therapeutics)Hepa-Merz Granules 6000 ↗Higher-strength sachet supplying 6 g L-ornithine-L-aspartate per dose; pharmaceutical product for hepatic encephalopathy.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of L-Ornithine-L-Aspartate
Top L-Ornithine-L-Aspartate manufacturers in China.
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source L-Ornithine-L-Aspartate
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your L-Ornithine-L-Aspartate out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load L-Ornithine-L-Aspartate together with other ingredients such as Glycine, L-Arginine and L-Leucine into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
L-Ornithine-L-Aspartate is registered as a prescription drug in numerous European, Latin American, and Asian markets for the management of hepatic encephalopathy.
The substance is not assigned a food additive E number and is not approved as a food flavouring or processing aid. Where used in dietary supplements, both component amino acids carry GRAS standing in the United States, with the salt itself marketed under the DSHEA framework.
European Medicines Agency member-state authorisations cover both oral and intravenous dosage forms. Standard branded products include Hepa-Merz (Merz Pharmaceuticals), originally launched in the 1970s.
The substance is listed in the European Pharmacopoeia. Pharmacopoeial monographs for the individual amino acids L-ornithine and L-aspartic acid appear in the USP and JP, though a combined-salt monograph is less universal.
Halal and Kosher certifications exist for fermentation-derived material, since both precursors are produced from plant-based feedstocks.
Manufacturing Process
L-Ornithine-L-Aspartate is manufactured by independent fermentation of each precursor followed by aqueous salt formation.
L-ornithine is produced by aerobic fermentation using engineered Corynebacterium glutamicum, with knockout of arginine biosynthesis pushing flux to ornithine accumulation. Broth titers above 50 g/L are routine on glucose or molasses feedstock.
L-aspartic acid is produced by enzymatic conversion of fumaric acid using immobilized Escherichia coli aspartase, a long-established industrial bioprocess that delivers near-quantitative yields and high optical purity.
The two amino acids are dissolved in deionized water in equimolar ratio, the solution is decolorised over activated carbon, concentrated under vacuum, and crystallised as the 1:1 salt. Crystals are filtered, washed with ethanol, vacuum-dried, milled to specification, and packed under nitrogen to limit moisture pickup.
