Riboflavin Sodium Phosphate
Riboflavin Sodium Phosphate is the sodium salt of riboflavin 5'-monophosphate and the water-soluble form of Vitamin B2 used in clear beverages, parenteral nutrition, and any application where native riboflavin's poor solubility creates a formulation problem.
It is an orange to yellow-orange crystalline powder with the molecular formula C₁₇H₂₀N₄NaO₉P and a molar mass of 478.33 g/mol. Compared with the parent vitamin (water solubility around 80 mg/L), the sodium phosphate ester dissolves freely at roughly 100 g/L, which is the practical reason it exists as a separate commercial article.
We source bulk Riboflavin Sodium Phosphate from top China manufacturers for our partners. The manufacturers are in Jiangxi and Shandong. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
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- Packaging
- 20 kg fibre drum, light-shielded
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | Yellow to orange crystalline powder |
| Assay (dry basis) | 73.0% to 79.0% (as Riboflavin) |
| Specific rotation | +38° to +43° |
| Loss on drying | ≤ 8.0% |
| Water solubility (20 °C) | ≥ 100 mg/mL |
| Heavy metals (as Pb) | ≤ 10 mg/kg |
| Free Riboflavin | ≤ 6.0% |
| Inorganic phosphate | ≤ 2.0% |
Common Markets Grades
Riboflavin Sodium Phosphate is produced against pharmacopoeial assay specifications.
The standard pharmaceutical grade meets USP, Ph. Eur., and JP monographs, with assay typically reported on an anhydrous and free-riboflavin-corrected basis. Total riboflavin phosphate esters run around 73 to 79 percent of the labelled value because the commercial product is a mixture of the 5'-monophosphate (dominant) with smaller amounts of other phosphate isomers and free riboflavin.
A food-grade fraction with the same chemical profile and a relaxed documentation package is produced for beverage fortification and pharmaceutical-equivalent supplement use.
Material is normally micronized to pass 100 mesh for fast dissolution in cold water without need for heating or mechanical shear.
Applications
- Clear and translucent fortified beverages where native riboflavin would settle out
- Sports drinks, electrolyte mixes, and ready-to-drink B-vitamin shots
- Effervescent tablets and dissolvable drink sticks
- Parenteral nutrition concentrates and injectable B-complex solutions
- Pediatric drops and oral syrups
- Liquid multivitamin tonics
- Yellow tinting of clear beverages and confectionery under E101(ii)
- Pharmaceutical solutions for intravenous, intramuscular, and subcutaneous administration
- Ophthalmic and topical preparations
- Aquaculture and livestock liquid feed supplements
- Veterinary injectable formulations
Brands Using Riboflavin Sodium Phosphate
Widely-distributed consumer products that list Riboflavin Sodium Phosphate on the ingredient label.
- Pure EncapsulationsB-Complex Liquid ↗Liquid B-Complex formulates Riboflavin (B2) as riboflavin 5'-phosphate sodium 3 mg per 5 ml serving.Label verified 2026-05-24
- ThorneRiboflavin 5'-Phosphate ↗Single-ingredient supplement providing the bioactive coenzyme form of vitamin B2 (riboflavin 5'-phosphate sodium).Label verified 2026-05-24
- Enfamil (Mead Johnson)Poly-Vi-Sol Liquid Multivitamin Supplement ↗Infant liquid multivitamin lists riboflavin-5-phosphate sodium among the ingredient panel.Label verified 2026-05-24
- ChildLife EssentialsMulti Vitamin & Mineral (Orange/Mango) ↗Liquid kids multivitamin lists Riboflavin (as Riboflavin-5-Phosphate) on the Supplement Facts panel.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Riboflavin Sodium Phosphate
Top Riboflavin Sodium Phosphate manufacturers in China.
- Jiangxi Dexing PARCHN Sodium Isovitamin C Co., Ltd.4 ingredients in the directory
Xintai Jiahe Biotech Co., Ltd.（新泰市佳禾生物科技有限公司）10 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Riboflavin Sodium Phosphate
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Riboflavin Sodium Phosphate out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Riboflavin Sodium Phosphate together with other ingredients such as Vitamin C, Vitamin D3 and Vitamin E into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Riboflavin Sodium Phosphate is approved as a colour additive and nutrient in essentially every regulated market.
In the European Union it carries the E number E101(ii), and Regulation (EC) 1333/2008 permits it. U.S. FDA approves it as a colour additive exempt from certification under 21 CFR 73.450 and as a nutrient under GRAS.
JECFA has set a group ADI for riboflavin and its phosphate esters together. Pharmacopoeial monographs appear in USP, Ph. Eur., and JP.
Halal and Kosher certifications are routinely available when the upstream riboflavin is produced on a plant-based fermentation medium.
Manufacturing Process
Riboflavin Sodium Phosphate is produced from riboflavin in a single phosphorylation step.
Fermentation-derived riboflavin, typically from a Bacillus subtilis or Ashbya gossypii process, is the starting material. The 5'-hydroxyl group is selectively phosphorylated using a phosphorus oxychloride or polyphosphoric acid reagent under controlled temperature and pH.
The crude product is a mixture of the desired 5'-monophosphate with smaller amounts of 4'- and 3'-isomers and unreacted riboflavin. The reaction mixture is quenched, neutralised with sodium hydroxide to form the sodium salt, and concentrated under vacuum.
Final purification is by precipitation from a controlled water-ethanol or water-acetone system. The product is filtered, washed, and dried to give the characteristic orange-yellow crystalline powder.
