CAS 58-56-0

Vitamin B6

Vitamin B6 is a family of three interconvertible pyridine derivatives: pyridoxine, pyridoxal, and pyridoxamine. The commercial form is pyridoxine hydrochloride (CAS 58-56-0), sold to the food, supplement, pharmaceutical, and feed industries.

All three forms are converted in the body to pyridoxal 5-phosphate (PLP), the active cofactor for more than 140 enzymes including transaminases, decarboxylases, and the synthesis of heme, serotonin, and gamma-aminobutyric acid.

We source bulk Vitamin B6 from top China manufacturers for our partners. The manufacturers are in Jiangxi and Zhejiang. For this ingredient the minimum order is 500 kg and a 20-foot container takes 8 MT, and a smaller requirement can ship in a combined container with other ingredients.

Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.

or call +86-21-6858 0751

Minimum order: 500 kg
Qty in 20' FCL: 8 MT
Packaging: 25 kg kraft paper bag with PE inner liner

ISO 9001
HACCP
Halal
Kosher

Specifications

Item	Specification
Appearance	White to almost white crystalline powder
Assay (dry basis)	98.0% to 101.0%
Loss on drying	≤ 0.5%
Residue on ignition	≤ 0.1%
pH (5% solution)	2.5 to 3.5
Chloride content	17.0% to 18.0%
Heavy metals (as Pb)	≤ 10 mg/kg
Arsenic	≤ 3 mg/kg
Particle size	Per customer specification

Common Markets Grades

Pyridoxine hydrochloride dominates commercial supply. It meets 98 to 101 percent assay against the USP, Ph. Eur., and JP monographs.

The standard fine-powder grade serves dietary supplements, multivitamin tablets, and pharmaceutical use. Granulated and direct-compression grades are produced for high-speed tableting and effervescent applications.

Feed-grade pyridoxine hydrochloride at 98 percent is produced for poultry, swine, dairy, and aquaculture premixes. Spray-dried and coated variants improve stability in mineral-rich premixes and extruded feeds.

Pyridoxal 5-phosphate (P5P) is a finished-form active used for premium supplement positioning. It runs at 98 percent assay as the monohydrate and commands a price premium over pyridoxine HCl based on the claim of bypassing hepatic phosphorylation, though the clinical relevance is modest in healthy adults.

Pyridoxamine dihydrochloride is produced at niche scale for research and specialty supplement use.

Applications

Multivitamin tablets, capsules, gummies, and powders as a B-complex component
Standalone B6 supplements for premenstrual syndrome, morning sickness, and homocysteine support
Energy drinks and sports-nutrition products as part of the B-vitamin complex
Infant formula and follow-on formula to meet Codex compositional standards
Cereal and flour fortification in countries with voluntary or mandatory B-vitamin programs
Clinical and enteral nutrition formulas for hospital and tube feeding
Pharmaceutical preparations for pyridoxine-responsive seizures and isoniazid-induced neuropathy
Antiemetic combinations using pyridoxine with doxylamine for pregnancy nausea
Animal feed premixes for poultry, swine, dairy, and aquaculture
Pet food fortification across dry, wet, and treat formats
Premium P5P supplements positioned at consumers concerned about conversion capacity
Research and reference reagents for amino-acid metabolism studies

Brands Using Vitamin B6

Widely-distributed consumer products that list Vitamin B6 on the ingredient label.

Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.

China Manufacturers of Vitamin B6

Top Vitamin B6 manufacturers in China.

Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.

How We Help Source Vitamin B6

Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Vitamin B6 out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Vitamin B6 together with other ingredients such as Vitamin C, Vitamin D3 and Vitamin E into one 20' FCL. If your quantity is small, we can also ship LCL.

Regulatory Status

Vitamin B6 is approved as a nutrient in essentially every regulated market.

In the European Union Regulation (EC) No 1925/2006 authorises pyridoxine hydrochloride, pyridoxal 5-phosphate, and pyridoxamine dihydrochloride for food fortification, and Directive 2002/46/EC authorises them for food supplements. EFSA reviewed the upper intake level in 2023 and reduced it to 12 mg/day for adults, reflecting evidence on peripheral neuropathy at chronic high intake.

The U.S. Food and Drug Administration recognises pyridoxine hydrochloride as GRAS under 21 CFR 184.1676. The Institute of Medicine has set a tolerable upper intake level of 100 mg/day in adults.

JECFA has reviewed pyridoxine and assigned it acceptable nutrient status. Pharmacopoeial monographs appear in the USP, Ph. Eur., JP, and BP.

Halal and Kosher certifications are widely available given the fully synthetic supply chain. Cosmetic use of pyridoxine and its derivatives is listed in the EU CosIng database.

Manufacturing Process

Vitamin B6 Manufacturing Process

Loading process diagram…

Industrial pyridoxine hydrochloride is produced by chemical synthesis. Several routes have been operated commercially, all building the pyridine ring with the correct substitution pattern of hydroxyl, hydroxymethyl, and methyl groups.

The most widely used route is the Diels-Alder approach pioneered by Merck and refined by Daiichi and several Chinese producers. 4-methyl-5-alkoxyoxazole is reacted with a dienophile such as dimethyl maleate or 2-butene-1,4-diol, and the bicyclic intermediate is opened and aromatized to the pyridoxine skeleton.

The product is acidified with hydrochloric acid to give the crystalline hydrochloride salt, recrystallised from aqueous ethanol, and dried to pharmacopoeial purity. For pyridoxal 5-phosphate, pyridoxine is oxidised to pyridoxal and then phosphorylated chemically or enzymatically.

Production is concentrated in a small number of Chinese plants, with smaller volumes from India. Pyridoxine is one of the more synthesis-intensive B vitamins, and the cost structure reflects multiple stages and stringent quality control.