Casein Phosphopeptides
Casein Phosphopeptides, abbreviated CPP, are a family of phosphorylated peptides released from milk casein by enzymatic digestion. They are best known for their ability to bind and stabilise calcium and phosphate ions in amorphous, bioavailable form.
The defining structural feature is a cluster of phosphoserine residues separated by glutamic-acid residues, often summarised as the SerP-SerP-SerP-Glu-Glu motif. This cluster acts as a multidentate ligand for calcium and is the basis for nearly every application of CPP in food and oral care.
We source bulk Casein Phosphopeptides from top China manufacturers for our partners. The manufacturer is in Hubei. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
Grades / Types Available: Food Grade
| Item | Specification |
|---|---|
| Appearance | White to light yellow fine powder |
| CPP Content (dry basis) | ≥20% |
| Protein (N×6.38) | ≥80% |
| Moisture | ≤6.0% |
| Ash | ≤10% |
| Phosphorus | ≥2.5% |
| pH (1% sol.) | 6.0–7.5 |
| Solubility | ≥98% |
| Heavy Metals (as Pb) | ≤2 mg/kg |
| Total Plate Count | ≤10,000 cfu/g |
| Salmonella | Absent in 25g |
| Fat | 0.5% |
| Lactose | 0.3% |
| Degree of Hydrolysis | 10% |
Common Markets Grades
Standard food and supplement grades are off-white to pale yellow powders at a minimum CPP content of 80 percent, with the balance composed of non-phosphorylated peptides and minor lactose and ash.
Oral-care grades are CPP-ACP, a complex of casein phosphopeptide with amorphous calcium phosphate. This complex is the active ingredient in remineralizing toothpastes, dental crèmes, and chewing gums.
A CPP-ACFP variant, in which fluoride is co-stabilised with the calcium phosphate cluster, is produced for fluoride-containing dental products.
Pharmaceutical and clinical-nutrition grades carry tighter heavy-metal, microbiological, and endotoxin specifications, and are typically dispatched with full peptide-mapping data and phosphoserine-content assays.
Applications
- Remineralizing toothpastes and dental crèmes for early-stage caries lesions and post-bleaching sensitivity
- Sugar-free chewing gums positioned for tooth enamel support
- Mouth rinses and topical dental gels for in-office and at-home use
- Calcium-fortified beverages, yogurts, and dairy drinks where CPP improves calcium solubility
- Infant and follow-on nutrition products to support calcium and phosphate absorption
- Sports-nutrition powders and bars carrying calcium claims
- Bone-health supplements alongside vitamin D, vitamin K, and magnesium
- Functional confectionery such as remineralizing lozenges and sugar-free candies
- Clinical nutrition for patients with malabsorption or low calcium intake
- Mineral-fortified bakery products such as breads and breakfast cereals
Brands Using Casein Phosphopeptides
Widely-distributed consumer products that list Casein Phosphopeptides on the ingredient label.
- GC AmericaMI Paste Topical Tooth Creme ↗Professional topical tooth creme delivering RECALDENT (CPP-ACP), a milk-derived casein phosphopeptide-amorphous calcium phosphate complex that releases bio-available calcium and phosphate to remineralise enamel.Label verified 2026-05-24
- GC AmericaMI Paste ONE ↗Two-in-one toothpaste plus topical creme combining RECALDENT CPP-ACP technology with fluoride for daily enamel remineralisation and caries protection.Label verified 2026-05-24
- GCTooth Mousse ↗Sugar-free water-based remineralising creme that uses Recaldent CPP-ACP to deliver bio-available calcium and phosphate ions for enamel protection and reduced sensitivity.Label verified 2026-05-24
- TridentTrident Xtra Care Sugar Free Gum ↗Mondelez-owned Trident Xtra Care chewing gum is formulated with Recaldent (calcium casein peptone-calcium phosphate) to strengthen tooth enamel between brushings.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Casein Phosphopeptides
Top Casein Phosphopeptides manufacturers in China.
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Casein Phosphopeptides
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Casein Phosphopeptides out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Casein Phosphopeptides together with other ingredients such as Collagen Peptide, Soy Protein Isolate and Fish Collagen Peptide into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Casein phosphopeptides are accepted as food and supplement ingredients in major markets when produced from food-grade casein under sanitary conditions.
In the United States the ingredient operates under GRAS practice for use in foods, beverages, and dietary supplements. The CPP-ACP complex used in oral-care products is regulated through dental-product channels rather than food channels.
In the European Union, CPP is treated as a dairy-derived ingredient and is subject to milk-allergen labelling. Use in food contact and supplement applications follows the standard rules for hydrolysed milk-protein ingredients.
Halal and Kosher certifications are routinely available because the starting casein and the processing aids are compatible with both standards when properly sourced.
Manufacturing Process
Manufacture begins with bovine casein, either as acid casein or as caseinate. The casein is dissolved and subjected to controlled enzymatic hydrolysis with trypsin or a similar pancreatic protease.
The hydrolysate is then enriched in phosphopeptides by selective precipitation. Addition of calcium and ethanol or pH adjustment causes the phosphorylated peptides, which bind calcium tightly, to drop out of solution while the non-phosphorylated background remains soluble.
The phosphopeptide pellet is washed, redissolved, and may be passed over an ion-exchange or membrane step for further enrichment. Ultrafiltration removes residual large peptides and proteins.
The purified concentrate is dried, usually by spray drying, and blended to a target phosphopeptide content. CPP-ACP variants are produced by combining the dried CPP with calcium and phosphate ions under controlled pH to form the amorphous complex before final drying.
