Hesperitin
Hesperitin is a citrus flavanone aglycone (CAS 520-33-2) recognised for its role as the active metabolite of the more widely consumed glycoside hesperidin.
The compound has the formula C₁₆H₁₄O₆ and a molar mass of 302.28 g/mol. It is a pale yellow crystalline powder, sparingly soluble in water and freely soluble in dimethyl sulfoxide, ethanol, and dilute alkali.
We source bulk Hesperitin from top China manufacturers for our partners. The manufacturer is in Hunan. For this ingredient the minimum order is 200 kg, and a smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Minimum order
- 200 kg
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
Grades / Types Available: N/A
| Item | Specification |
|---|---|
| Appearance | White to off-white powder |
| Assay | ≥ 98.0% |
| Moisture | ≤ 1.0% |
| Heavy Metals (as Pb) | ≤ 10 mg/kg |
| Color | Yellow to dark brown |
| Odor | Characteristic |
| Purity | 10%-98% HPLC |
| Sieve Analysis | 95% through 80 mesh |
| Loss on Drying | ≤10% |
| Sulphated Ashes | ≤0.2% |
| Heavy Metal | ≤20PPM |
| Total Plate Count | <1000cfu/g Max |
| Non-GMO | Conform |
| Not Irradiated | Conform |
| Non-BSE | Conform |
| Kosher Certificate | Conform |
| Halal Certificate | Conform |
Common Markets Grades
Hesperitin is graded by purity of the aglycone fraction.
Standard food-supplement grade ranges from 90 to 95 percent assay by HPLC, recovered from enzymatic or acidic hydrolysis of hesperidin sourced from sweet orange (Citrus sinensis) peel.
A 98 percent pharmaceutical grade is produced for solid-dose formulation and clinical research, with tight controls on residual hesperidin, isosihesperidin, and solvent residues.
Reference material at 99 percent or higher is produced for analytical and pharmacopoeial calibration. Micronized and amorphous solid dispersion variants exist where dissolution rate is the limiting factor.
Applications
- Dietary supplements positioned for venous and capillary support, often alongside diosmin and rutin
- Cardiovascular and microcirculation formulas in softgel and tablet form
- Sports recovery blends targeting post-exercise oxidative stress
- Cognitive and neuroprotective stacks combined with citicoline or omega-3
- Functional beverages and shots fortified with citrus polyphenols
- Topical cosmetic serums for redness reduction and microvessel tone
- Sunscreen and after-sun products as a secondary antioxidant
- Veterinary supplements for canine and equine vascular support
- Reference standard for citrus-juice authenticity testing
- Pharmaceutical intermediate in the synthesis of methylated and prenylated flavanone analogs
- Nutricosmetic capsules for skin firmness and elasticity claims
- Specialty oral-care lozenges using anti-inflammatory positioning
Brands Using Hesperitin
Widely-distributed consumer products that list Hesperitin on the ingredient label.
- Nootropics DepotHesperidin Capsules 500 mg ↗Nootropics Depot's Hesperidin Capsules deliver 500 mg of 90% citrus extract per serving; hesperidin is the rutinoside form that converts in vivo to its bioactive aglycone hesperetin (hesperitin).Label verified 2026-05-24
- Swanson VitaminsHesperidin 500 mg ↗Swanson Premium Hesperidin supplies hesperidin, the citrus flavonoid glycoside that is metabolised to the aglycone hesperetin.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Hesperitin
Top Hesperitin manufacturers in China.
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Hesperitin
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Hesperitin out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Hesperitin together with other ingredients such as Arachidonic Acid, Coenzyme Q10 and Chondroitin Sulphate Sodium into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Hesperitin is not a standalone food additive. It is present as a minor constituent of permitted citrus extracts and citrus juice, with intake covered by general food law.
In the European Union it falls under Regulation (EC) No 178/2002 as a food constituent and is sold to manufacturers as a botanical extract or purified ingredient. No novel-food authorisation is required when sourced from edible citrus species at normal intake levels.
In the United States, hesperitin-containing citrus extracts are marketed as dietary-supplement ingredients under DSHEA. The aglycone itself has been the subject of self-affirmed GRAS notifications by individual suppliers.
EFSA has evaluated a related health claim on hesperidin and orange juice flavanones for endothelial function and issued an unfavorable opinion in 2010, citing insufficient evidence. No authorised EU health claim currently applies to hesperitin.
Pharmacopoeial monographs do not yet exist, although Chinese Pharmacopoeia entries cover related citrus flavonoids used as quality markers.
Manufacturing Process
Industrial hesperitin is obtained almost exclusively by hydrolysis of hesperidin.
Hesperidin itself is recovered from the peel, pith, and segment membranes of Citrus sinensis, Citrus reticulata, and Citrus aurantium, which are byproducts of orange juice processing in Brazil, Mexico, Spain, and Italy.
The glycoside is cleaved by either dilute mineral acid at elevated temperature or by α-L-rhamnosidase and β-D-glucosidase enzymes. Enzymatic hydrolysis offers cleaner isomer profiles and lower residual sugars but at higher unit cost.
The crude aglycone is then recrystallised from aqueous ethanol or methanol. Polishing chromatography on macroporous resin upgrades the material to pharmaceutical and reference-standard purities.
A small share of supply comes from semi-synthesis starting from naringenin via 3'-hydroxylation and 4'-O-methylation, used mainly where isotope-labelled or structurally modified hesperitin is required for research.
