Nucleotide
Nucleotide, as supplied for infant formula and adult nutrition, is a defined blend of the five 5'-monophosphates: adenosine (AMP), cytidine (CMP), guanosine (GMP), uridine (UMP), and inosine (IMP).
The blend approximates the nucleotide profile of human milk and is used to support the dietary pool available for rapidly dividing tissues, including the developing immune system and gut mucosa.
We source bulk Nucleotide from top China manufacturers for our partners. The manufacturer is in Jiangsu. For this ingredient the minimum order is 500 kg and a 20-foot container takes 10 MT, and a smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Minimum order
- 500 kg
- Qty in 20' FCL
- 10 MT
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder, odourless |
| Total 5'-Nucleotides (HPLC, dried basis) | ≥ 97.0% |
| Cytidine 5'-Monophosphate (CMP) | 35.0-45.0% of total nucleotides |
| Uridine 5'-Monophosphate (UMP) | 15.0-25.0% of total nucleotides |
| Adenosine 5'-Monophosphate (AMP) | 12.0-20.0% of total nucleotides |
| Guanosine 5'-Monophosphate (GMP) | 8.0-14.0% of total nucleotides |
| Inosine 5'-Monophosphate (IMP) | 8.0-15.0% of total nucleotides in the five-component blend; absent from the four-component blend |
| Individual Nucleotide Purity (single salts) | ≥ 98.0% each |
| Related Substances (total) | ≤ 1.0% |
| Loss on Drying | ≤ 6.0% |
| pH (1% aqueous solution) | 2.0-4.0 |
| Residue on Ignition | ≤ 0.5% (free-acid grades) |
| Heavy Metals (as Pb) | ≤ 5 mg/kg |
| Arsenic | ≤ 1 mg/kg |
| Total Plate Count | ≤ 1,000 cfu/g |
Common Markets Grades
The trade sells individual 5'-nucleotides and pre-mixed blends.
Individual sodium salts of AMP, CMP, GMP, UMP, and IMP run at 98 percent or higher purity. They are sold to formulators who blend in-house to their own ratio.
The standard infant-formula blend is a five-component mix with a ratio close to that of human milk, typically delivering total nucleotide at a few milligrams per 100 kcal in the finished formula.
A simpler four-component blend without IMP is produced for markets that follow that nutritional reference.
Adult supplement blends often include higher relative IMP for sports recovery positioning, where inosine pathway support is the reason for the formulation.
Applications
- Infant and follow-on formula as a human-milk-aligned nutrient blend
- Toddler and young-child nutritional powders
- Premature infant nutrition under clinical supervision
- Maternal nutrition products for pregnancy and lactation
- Adult immune-support supplements in capsule and tablet form
- Sports recovery products positioned around training-load immunity
- Clinical nutrition products for post-surgical and convalescent patients
- Geriatric nutrition products with immune-maintenance positioning
- Functional beverages and ready-to-drink shots
- Pet nutrition for puppies, kittens, and senior animals
- Aquaculture feed for shrimp and fish hatchery stages
Brands Using Nucleotide
Widely-distributed consumer products that list Nucleotide on the ingredient label.
- Enfamil (Mead Johnson)Enfamil NeuroPro Infant Formula ↗Enfamil NeuroPro lists the five nucleotides found in breast milk (cytidine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, disodium guanosine 5'-monophosphate and disodium inosine 5'-monophosphate) on its ingredient panel.Label verified 2026-05-24
- Similac (Abbott)Similac Sensitive Infant Formula ↗Similac Sensitive lists the nucleotides adenosine 5'-monophosphate, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate and disodium uridine 5'-monophosphate on its ingredient panel.Label verified 2026-05-24
- Earth's Best OrganicOrganic Dairy Infant Formula with Iron, DHA & ARA ↗Earth's Best Organic Dairy Infant Formula includes the five nucleotides (cytidine-, adenosine-, disodium uridine-, disodium guanosine- and disodium inosine-5'-monophosphate) found in breast milk.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Nucleotide
Top Nucleotide manufacturers in China.
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Nucleotide
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Nucleotide out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Nucleotide together with other ingredients such as Arachidonic Acid, Coenzyme Q10 and Chondroitin Sulphate Sodium into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
5'-Nucleotides are recognised in the Codex Alimentarius standard for infant formula as permitted optional ingredients, with the five-component blend reflecting the human-milk profile.
In the European Union, nucleotides are permitted for addition to infant formula and follow-on formula under the relevant Commission Delegated Regulation, with maximum levels set for each individual nucleotide.
In the United States, the individual 5'-nucleotides have GRAS status for use in infant formula and general food applications.
JECFA has reviewed the safety of nucleotide addition to infant formula at the levels relevant to commercial use.
Pharmacopoeial specifications for the individual sodium salts appear in the Japanese Pharmacopoeia and as reference monographs in food-additive compendia. Halal and Kosher certifications are routinely available.
Manufacturing Process
Industrial production of the individual 5'-nucleotides is dominated by microbial fermentation, with separate processes for the purine and pyrimidine series.
For the purine route, engineered Corynebacterium ammoniagenes or Bacillus subtilis strains are grown on glucose with controlled feeding to overproduce inosine or guanosine. The nucleoside is then phosphorylated chemically or enzymatically to yield the 5'-monophosphate.
For the pyrimidine route, fermentation strains overproducing orotic acid or uridine serve as the starting point. Conversion to UMP and CMP uses enzymatic phosphorylation followed by purification.
Downstream processing for all five nucleotides uses cell removal, activated carbon decolorisation, ion exchange, and crystallisation. The crystalline sodium salts are dried, milled, and sieved to a defined particle size.
Blending to the target five-nucleotide ratio is done in a dedicated clean area to maintain the homogeneity required for low-inclusion infant-formula use.
