Phloretin
Phloretin (CAS 60-82-2) is a dihydrochalcone polyphenol concentrated in apple peel, apple seeds, and the bark of various rosaceous trees.
The compound has the formula C₁₅H₁₄O₅ and a molar mass of 274.27 g/mol. It is a pale yellow crystalline powder, sparingly soluble in water and readily soluble in ethanol, propylene glycol, and most polar organic solvents.
We source bulk Phloretin from top China manufacturers for our partners. The manufacturers are in Hunan and Tianjin. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
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- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
Grades / Types Available: Pharmaceutical Grade, Food Grade
| Item | Specification |
|---|---|
| Appearance | White to off-white powder |
| Assay | ≥ 98.0% |
| Moisture | ≤ 1.0% |
| Heavy Metals (as Pb) | ≤ 10 mg/kg |
| Purity | ≥98% (Pharmaceutical Grade) |
| Moisture/Loss on Drying | ≤5% (Pharmaceutical Grade) |
| pH | 4.0-6.0 |
| Lead | ≤2 ppm |
| Arsenic | ≤1 ppm |
| Total Plate Count | ≤1000 cfu/g |
| Yeast & Mold | ≤100 cfu/g |
Common Markets Grades
Phloretin is graded by HPLC purity.
Cosmetic-grade phloretin is typically sold at 90 to 95 percent assay, recovered from apple (Malus domestica) processing byproducts and from Phloridzin-rich Rosaceae bark.
A 98 percent grade is used in serums and dietary supplements where the highest stated purity is wanted. Reference and pharmaceutical grades at 99 percent or higher are produced with full impurity profiling, including limits on phloridzin, naringenin chalcone, and residual solvent.
Glycosylated and acetylated derivatives such as phloretin glucoside and phloretin acetate are sometimes offered alongside the aglycone for formulation flexibility.
Applications
- Dermocosmetic antioxidant serums, often combined with vitamin C and ferulic acid
- Anti-aging creams positioned for environmental stress protection
- Sunscreen formulas as a secondary photoprotective antioxidant
- Brightening and even-tone products targeting hyperpigmentation pathways
- Skin barrier and microbiome-friendly leave-on emulsions
- Dietary supplements positioned around apple polyphenol antioxidant content
- Metabolic-support formulas drawing on SGLT inhibitor research
- Functional beverages and shots with apple polyphenol claims
- Hair-care leave-in conditioners for antioxidant protection
- Oral care lozenges and rinses with antibacterial positioning
- Research material for sugar transporter and skin permeability studies
- Reference standard for apple cultivar polyphenol profiling
Brands Using Phloretin
Widely-distributed consumer products that list Phloretin on the ingredient label.
- SkinCeuticalsPhloretin CF with Ferulic Acid ↗SkinCeuticals Phloretin CF antioxidant serum is built around a patented combination of 2% phloretin, 10% pure vitamin C (L-ascorbic acid), and 0.5% ferulic acid.Label verified 2026-05-24
- SkinCeuticalsPhloretin CF Gel ↗SkinCeuticals Phloretin CF Gel is the lightweight gel formulation of the same patented 2% phloretin + vitamin C + ferulic acid antioxidant complex for daytime environmental protection.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Phloretin
Top Phloretin manufacturers in China.
Lianyuan Kang Biotech. Co., Ltd.7 ingredients in the directory
Tianjin Jianfeng Natural Product R&D Co., Ltd.8 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Phloretin
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Phloretin out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Phloretin together with other ingredients such as Arachidonic Acid, Coenzyme Q10 and Chondroitin Sulphate Sodium into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Phloretin is a natural constituent of apple fruit and apple-derived foods, and intake from foods is governed by general food law.
In the European Union, phloretin is treated as a botanical-derived ingredient under Regulation (EC) No 178/2002 when sold as part of standardised apple extracts. It also appears on the European cosmetic ingredient inventory (CosIng) for use in finished cosmetic products under Regulation (EC) No 1223/2009.
In the United States, phloretin is widely used in cosmetic skincare products marketed under FDA cosmetic regulations and is included in several self-affirmed GRAS dossiers for apple polyphenol extracts.
No authorised EU health claim references phloretin specifically. Pharmacopoeial monographs for the pure compound do not yet exist, but pharmacopoeial apple-leaf and apple-peel reference texts are under development in several jurisdictions.
For cosmetic use, the SCCS has not flagged safety concerns at typical leave-on use levels of 0.1 to 2 percent.
Manufacturing Process
Industrial phloretin comes mainly from hydrolysis of phloridzin.
Phloridzin (phloretin-2'-O-glucoside) is recovered from apple processing residues, apple seedling root bark, and the bark of selected pear and cherry rootstocks. China and central Europe supply most of the raw material.
The glycoside is cleaved by β-glucosidase enzyme or by dilute acid at elevated temperature to release the free dihydrochalcone. Enzymatic hydrolysis is preferred for cosmetic grades because it minimises side products and residues.
The crude phloretin is recrystallised from aqueous ethanol or methanol. Activated carbon polishing, ion-exchange treatment, and final preparative chromatography deliver pharmaceutical and reference-grade material.
A small synthetic share is produced by hydrogenation of naringenin chalcone or by Friedel-Crafts acylation of phloroglucinol with 4-hydroxyphenylpropionic acid derivatives. Synthetic material is identical to the natural compound, which lacks chirality.
