S-Adenosyl-L-Methionine Disulfate Tosylate
S-Adenosyl-L-Methionine Disulfate Tosylate is a stable double salt of the universal methyl-donor cofactor SAMe, paired with sulphate and p-toluenesulfonate counter-ions to slow the decomposition that plagues free-base SAMe.
The compound has the formula C₁₅H₂₂N₆O₅S·2H₂SO₄·C₇H₈O₃S, a molar mass near 766.8 g/mol, and CAS number 97540-22-2. It is the dominant commercial form for SAMe dietary supplements, since the unstabilized free base degrades within hours at room temperature.
We source bulk S-Adenosyl-L-Methionine Disulfate Tosylate from top China manufacturers for our partners. The manufacturer is in Jiangxi. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | Off-white to pale yellow crystalline powder, hygroscopic |
| Identification | Infrared spectrum and HPLC retention conform to reference standard |
| SAMe Content (as the free ion, HPLC, dry basis) | ≥ 65.0% |
| Assay (as the disulfate tosylate salt, dry basis) | ≥ 98.0% |
| (S,S)-Isomer (of total SAMe, chiral HPLC) | ≥ 68.0% |
| Water (Karl Fischer) | ≤ 5.0% |
| Specific Rotation [α]D20 | +32.0° to +38.0° (c = 1, water) |
| pH (1% aqueous solution) | 1.5 to 2.5 |
| Related Substances | Any single impurity ≤ 1.0%; total ≤ 3.0% |
| Residue on Ignition | ≤ 0.5% |
| Heavy Metals (as Pb) | ≤ 10 mg/kg |
| Lead (Pb) | ≤ 1 mg/kg |
| Arsenic (as As) | ≤ 1 mg/kg |
| Total Plate Count | ≤ 1,000 cfu/g |
| Yeast and Mould | ≤ 100 cfu/g |
Common Markets Grades
Two specifications cover S-Adenosyl-L-Methionine Disulfate Tosylate, pharmaceutical and nutraceutical, and both express assay on a SAMe-equivalent basis rather than on total salt weight.
The dominant commercial format holds 65 to 70 percent active SAMe equivalent on the dry basis, reflecting the molecular weight contribution of the sulphate and tosylate counter-ions. Higher-active 80 percent grades are produced for capsule and enteric-coated tablet applications where dose density matters.
Pharmaceutical grade meets the European Pharmacopoeia monograph and is produced for prescription tablet manufacture in markets where SAMe is registered as a drug. The grade carries tighter limits on related substances and bacterial endotoxins.
Nutraceutical grade is produced for enteric-coated dietary supplement tablets, the standard delivery format for oral SAMe. All grades are packed under nitrogen in foil-laminate pouches with desiccant and kept under refrigeration in transit.
Applications
- Enteric-coated dietary supplement tablets for mood support claims
- Joint health and osteoarthritis supplement blends
- Liver-support nutraceutical formulas paired with milk thistle
- Prescription tablets for depression and dysthymia in registered markets
- Adjunctive use in hepatic disorders including cholestasis and cirrhosis
- Osteoarthritis prescription preparations in European clinical practice
- Veterinary hepatic-support formulations in canine and feline medicine
- Fibromyalgia and chronic-pain supplement blends
- Combination products with vitamin B12, folate, and B6 for methylation support
- Research reagent in methylation biochemistry and epigenetic studies
- Adjunctive cognitive-support supplements in older adult populations
- Specialty mental-wellness blends positioned around neurotransmitter synthesis
Brands Using S-Adenosyl-L-Methionine Disulfate Tosylate
Widely-distributed consumer products that list S-Adenosyl-L-Methionine Disulfate Tosylate on the ingredient label.
- Nature MadeSAM-e Complete 400 mg Tablets ↗An enteric-coated tablet supplying 400 mg SAM-e as S-adenosyl-L-methionine disulfate tosylate.Label verified 2026-05-24
- Nature MadeSAM-e Complete 200 mg ↗Lower-strength enteric-coated SAM-e tablet supplying 200 mg per tablet for daily mood and joint support.Label verified 2026-05-24
- Jarrow FormulasSAMe 400 mg Enteric-Coated Tablets ↗Foil blister-packed enteric tablet delivering 400 mg S-adenosyl-L-methionine derived from 800 mg SAMe tosylate disulfate.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of S-Adenosyl-L-Methionine Disulfate Tosylate
Top S-Adenosyl-L-Methionine Disulfate Tosylate manufacturers in China.
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source S-Adenosyl-L-Methionine Disulfate Tosylate
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your S-Adenosyl-L-Methionine Disulfate Tosylate out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load S-Adenosyl-L-Methionine Disulfate Tosylate together with other ingredients such as Glycine, L-Arginine and L-Leucine into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
S-Adenosyl-L-Methionine carries split regulatory status depending on market.
In Italy, Spain, Germany, and several other European Union member states, SAMe is registered as a prescription drug for depression, liver disease, and osteoarthritis, with branded products including Samyr (Abbott) and Donamet (Knoll).
In the United States it is sold as a dietary supplement under DSHEA, having been the subject of multiple New Dietary Ingredient notifications since 1999. It is not approved by the FDA as a drug.
In Canada it is regulated as a natural health product with an assigned Natural Product Number under the NHPD framework. Australia and New Zealand similarly regulate it as a complementary medicine listed with the TGA.
Pharmacopoeial monographs for the disulfate tosylate salt appear in the European Pharmacopoeia. The substance is not assigned a food additive E number and is not approved as a food flavouring or processing aid.
Manufacturing Process
Commercial S-Adenosyl-L-Methionine is produced exclusively by yeast fermentation, since chemical synthesis cannot deliver the required optical purity at usable cost.
The strain of choice is Saccharomyces cerevisiae, typically a high-producing brewing or sake-yeast derivative. Fermentation is carried out aerobically on a glucose or molasses feedstock with L-methionine supplementation at the late log phase, which dramatically boosts intracellular SAMe accumulation.
At harvest, the yeast cells contain 1 to 4 percent SAMe on dry weight. Cells are lysed by acid extraction at low temperature, the SAMe is captured on a cation-exchange resin, eluted, and converted to the disulfate tosylate salt by sequential addition of sulphuric acid and p-toluenesulfonic acid.
The salt is crystallised from a water-ethanol system at low temperature, washed with cold ethanol, vacuum-dried below 30 °C, and packed under nitrogen with desiccant. The entire downstream process is kept at low temperature and short residence time to limit decomposition to S-adenosylhomocysteine.
