Beta-Cyclodextrin
Beta-Cyclodextrin is a cyclic oligosaccharide built from seven D-glucose units linked head-to-tail by α-1,4 glycosidic bonds, forming a truncated cone shape.
The cone has a hydrophobic interior cavity and a hydrophilic outer surface, which lets it form host-guest inclusion complexes with small organic molecules of suitable size and polarity.
This molecular encapsulation behaviour is the basis for its commercial use as a flavour stabiliser, masking agent, controlled-release matrix, and solubility enhancer in food, pharmaceutical, cosmetic, and agrochemical formulations.
We source bulk Beta-Cyclodextrin from top China manufacturers for our partners. The manufacturers are in Jiangsu and Shaanxi. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | White crystalline powder |
| Assay (dry basis) | ≥ 98.0% |
| Water content | ≤ 14.0% |
| pH (1% solution) | 5.0 to 8.0 |
| Specific rotation | +160° to +164° |
| Reducing sugars (as dextrose) | ≤ 1.0% |
| Residue on ignition | ≤ 0.20% |
| Particle size | ≥ 95% through 80 mesh |
| Residual complexant | ≤ 1 mg/kg |
| Lead | ≤ 0.5 mg/kg |
| Arsenic | ≤ 0.5 mg/kg |
| Total plate count | ≤ 1,000 cfu/g |
| Yeast and mold | ≤ 100 cfu/g |
| E. coli | Negative in 5 g |
| Salmonella | Negative in 25 g |
| Source | Enzymatic conversion of corn or potato starch |
Common Markets Grades
Purity and sales channel set the grades of Beta-Cyclodextrin.
Food grade meets the JECFA and Codex specifications for use as a food carrier and stabiliser.
Pharmaceutical grade meets the USP-NF, European Pharmacopoeia, and Japanese Pharmacopoeia monographs for use as a drug excipient.
Derivatized grades (hydroxypropyl-β-cyclodextrin, sulfobutyl ether-β-cyclodextrin) offer higher water solubility than the parent compound and unlock injectable pharmaceutical use.
Methylated and amino-functional grades exist for analytical chemistry and chiral separation columns.
Applications
- Encapsulation and stabilisation of volatile flavours in dry beverage and seasoning powders
- Bitterness masking in functional beverages and oral pharmaceutical liquids
- Cholesterol reduction in dairy products such as low-cholesterol butter and cheese
- Solubility enhancement of poorly water-soluble drugs in oral solid dose
- Controlled-release matrix in oral tablets and topical creams
- Stabilisation of essential oils in personal care and home fragrance products
- Removal of off-odours in textile finishing and air-freshener products
- Carrier for spray-dried flavours and fragrances
- Mould-release and anti-staling agent in bakery
- Stabiliser for unstable cosmetic actives such as retinol and vitamin C
- Chiral selector in analytical and preparative chromatography
China Manufacturers of Beta-Cyclodextrin
Top Beta-Cyclodextrin manufacturers in China.
Jiangsu Ogo Biotech Co., Ltd.9 ingredients in the directory- Shanxi Zhiqi Biotechnology Co., Ltd.6 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Beta-Cyclodextrin
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Beta-Cyclodextrin out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Beta-Cyclodextrin together with other ingredients such as Fructooligosaccharides, Dextrose and Dextrose Monohydrate into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Beta-Cyclodextrin is approved as a food additive in the European Union under E459 and is permitted for specific applications including as a carrier and flavour stabiliser.
The U.S. FDA accepts it under GRAS notification GRN 000074 for use in foods at functional levels.
JECFA has reviewed it and assigned an acceptable daily intake.
Pharmacopoeial monographs appear in the USP-NF, European Pharmacopoeia, and Japanese Pharmacopoeia under Betadex (Beta-Cyclodextrin).
Manufacturing Process
Beta-Cyclodextrin is produced by enzymatic conversion of starch.
Cleaned starch is gelatinized, liquefied with α-amylase to a low-DE substrate, then incubated with cyclodextrin glucanotransferase (CGTase) from Bacillus species. The CGTase cleaves the linear α-1,4 chains and rejoins them into cyclic structures.
The crude reaction mass is a mixture of α-, β-, and γ-cyclodextrins together with linear oligosaccharides. Selective precipitation of the β-cyclodextrin with toluene or a similar complexant uses its low water solubility to drive yield and purity.
The complex is broken, residual organics are removed by steam stripping and activated carbon, and the cyclodextrin is crystallised from water.
The crystals are washed, dried, milled, and packed.
