L-Valine
L-Valine is an essential branched-chain α-amino acid with the formula C₅H₁₁NO₂ and a molar mass of 117.15 g/mol. Its compact isopropyl side chain makes it strongly hydrophobic and a frequent contributor to protein hydrophobic cores and α-helix bundles.
The white crystalline powder is sparingly soluble in cold water and faintly bitter. Together with L-leucine and L-isoleucine, valine completes the branched-chain trio that drives skeletal-muscle amino acid metabolism.
We source bulk L-Valine from top China manufacturers for our partners, working with several of them. The manufacturers are in Anhui, Hebei and Jiangsu. For this ingredient the minimum order is 500 kg and a 20-foot container takes 20 MT, and a smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Minimum order
- 500 kg
- Qty in 20' FCL
- 20 MT
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
Grades / Types Available: CP2020, EP11, USP2023, USP24, AJI92, FCC11, High Purity, Instant, Granulation
| Item | Specification |
|---|---|
| Appearance | White crystalline powder |
| Assay | ≥98.5% |
| Specific Rotation [α]D20 | +26.5° to +29.0° |
| Loss on Drying | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| pH (1% solution) | 5.5–7.0 |
| Heavy Metals (as Pb) | ≤10 ppm |
| Arsenic | ≤1 ppm |
| Chloride | ≤0.02% |
| Total Plate Count | ≤1000 CFU/g |
| Transmittance(T430) (CP2020) | ≥98.0% |
| Sulfate(SO4) (CP2020) | ≤0.03% |
| Iron(Fe) (CP2020) | ≤10PPM |
| Moulds & Yeasts (CP2020) | ≤ 100 CFU/g |
Common Markets Grades
Four grades of L-Valine reach the market: food, supplement, pharmaceutical and feed.
Food and supplement grade L-valine meets the FCC monograph at 98.5 to 101.5 percent assay on the dried basis. Particle size and bulk density are tuned for BCAA dry-blend powders and ready-to-mix beverage formats.
Pharmaceutical grade L-valine conforms to USP, Ph. Eur., and JP monographs and is used in parenteral nutrition admixtures, oral amino-acid preparations, and as a chiral starting material for active pharmaceutical ingredients.
Cell-culture and biochemical grades are produced with low endotoxin counts and verified absence of contaminating amino acids. Feed grade L-valine is graded at lower assay specifications for high-performance swine diets, where it has become a routine fourth limiting amino acid alongside lysine, threonine, and tryptophan.
Applications
- Sports nutrition: BCAA powders blended in the classic 2:1:1 leucine-isoleucine-valine ratio
- Intra-workout and recovery drinks for amino acid replenishment
- Component of parenteral nutrition admixtures for surgical recovery and trauma
- Clinical-nutrition products for hepatic encephalopathy and metabolic stress
- Nutritional fortification of infant formula and follow-on nutrition products
- Cell-culture and fermentation media for biopharmaceutical manufacture
- Building block in peptide synthesis and pharmaceutical chiral intermediate chemistry
- Starting material for the synthesis of antiviral nucleoside prodrugs such as valacyclovir and valganciclovir
- Cosmetic skin-conditioning agent in amino-acid blend lotions and serums
- Animal feed supplement in low-protein swine and poultry diets
- Reagent in clinical chemistry kits that measure branched-chain amino acid panels
Brands Using L-Valine
Widely-distributed consumer products that list L-Valine on the ingredient label.
- BulkSupplementsL-Valine Powder ↗Pure L-Valine BCAA powder, unflavored, dosed at 2 g per serving with no added fillers or additives.Label verified 2026-05-24
- Transparent LabsBCAA Glutamine ↗Supplement Facts list L-Valine 2,000 mg per serving as part of the Fermented Vegan BCAA 2:1:1 blend.Label verified 2026-05-24
- DymatizeBCAA Complex 5050 ↗5,050 mg BCAA complex with 25% L-Valine (about 1,263 mg) alongside 50% L-Leucine and 25% L-Isoleucine.Label verified 2026-05-24
- MyProteinBCAA 4:1:1 Powder ↗Unflavored BCAA 4:1:1 powder contains 17% L-Valine alongside 66% L-Leucine and 17% L-Isoleucine.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of L-Valine
Top L-Valine manufacturers in China.
Anhui Huaheng Biotechnology Co.，Ltd.8 ingredients in the directory
Shijiazhuang Haitian Amino Acid Co., Ltd.11 ingredients in the directory
Wuxi Jinghai Amino Acid Co., Ltd.18 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source L-Valine
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your L-Valine out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load L-Valine together with other ingredients such as Glycine, L-Arginine and L-Leucine into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
L-Valine is broadly accepted as a food ingredient, dietary supplement, and pharmaceutical ingredient.
In the United States it is recognised as a nutrient and dietary supplement, with use in infant formula governed by the Infant Formula Act. Independent GRAS notices cover use in conventional foods, sports beverages, and clinical-nutrition products.
The European Union permits L-valine as a nutrient added to foods for particular nutritional uses, infant formula, and food supplements under Regulation (EU) No 609/2013. Regulation (EC) No 1831/2003 authorises feed grade L-valine as a nutritional additive for all animal species.
USP, Ph. Eur., JP, and BP monographs cover pharmaceutical applications. Halal and Kosher certifications are routinely available for fermentation-derived material that uses plant-based feedstocks and non-animal nitrogen sources.
Manufacturing Process
The dominant industrial route is direct fermentation of glucose by engineered Corynebacterium glutamicum strains. The valine biosynthesis pathway begins at pyruvate, runs through acetolactate, dihydroxyisovalerate, and 2-ketoisovalerate, and ends with a transamination step that delivers L-valine.
Productive strains carry feedback-resistant acetohydroxyacid synthase, amplified expression of the ilv operon, attenuated leucine and isoleucine outflows, and an enhanced supply of pyruvate. Sugar feed rate, dissolved oxygen, and ammonia control are critical because the pathway competes for pyruvate with valine's two sister BCAAs and with the tricarboxylic acid cycle.
Downstream processing follows the standard amino-acid train. Cells are removed by ultrafiltration, the broth is acidified, and the amino acid is captured on cation-exchange resin, eluted with ammonia, decolorised, concentrated, and crystallised from aqueous alcohol. A second recrystallisation gives food and pharmaceutical grades.
Chemical synthesis via the Strecker route on isobutyraldehyde gives the racemic DL form and requires resolution to extract pure L-valine. The route is not competitive with fermentation and is reserved for small specialty volumes.
