Pinosylvin
Pinosylvin is a stilbenoid, chemically 3,5-dihydroxy-trans-stilbene, with formula C14H12O2 and molar mass 212.24 g/mol. It is the parent stilbene of the pine genus and differs from resveratrol in lacking the 4'-hydroxyl group on the second aromatic ring, which makes it markedly more lipophilic and a stronger antifungal agent than resveratrol.
The compound is a phytoalexin, produced in the heartwood and bark of Pinus species in response to wounding and fungal attack, and it accumulates naturally in pine heartwood and knotwood. Its methyl ether pinosylvin monomethyl ether normally occurs alongside it, and commercial extracts usually report both.
Commercial pinosylvin is an off white to pale yellow crystalline powder, practically insoluble in water, soluble in ethanol, acetone and dimethyl sulphoxide, and soluble in oils and glycols used for topical formulation. Like all stilbenes it isomerises from the trans to the less active cis form under ultraviolet light, so the material is handled in light resistant packaging and formulated away from strong illumination.
We source bulk Pinosylvin from top China manufacturers for our partners. The manufacturer is in Zhejiang. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Function
- Plant extract
Specifications
| Item | Specification |
|---|---|
| Appearance | Off white to pale yellow crystalline powder |
| Assay (HPLC) | ≥ 98.0% |
| trans Isomer Content | ≥ 97.0% of total |
| Identification | Conforms by HPLC retention and UV spectrum |
| Melting Range | 154 to 158°C |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.5% |
| Particle Size | 100% through 80 mesh |
| Residual Ethanol | ≤ 0.5% |
| Residual Acetone | ≤ 0.5% |
| Heavy Metals (as Pb) | ≤ 10 mg/kg |
| Lead | ≤ 1.0 mg/kg |
| Arsenic | ≤ 1.0 mg/kg |
| Total Plate Count | ≤ 1,000 cfu/g |
| Yeast and Mould | ≤ 100 cfu/g |
Common Markets Grades
Trade divides into standardised pine bark or knotwood extracts, in which pinosylvin is reported as a marker alongside other stilbenes at levels of a few percent up to around 20 percent, and purified pinosylvin sold at 95 and 98 percent as an isolated compound. Purified material is quoted with trans isomer content stated separately from total assay, because the cis form is generated during handling and is not counted as active.
Physical supply is limited to crystalline powder of defined particle size, usually passing 80 mesh, and to pre-dispersed liquid concentrates in propylene glycol or ethanol at 1 to 5 percent for cosmetic incorporation. Because pinosylvin is not authorised as a food ingredient in the major markets, the grades in circulation are cosmetic, research and technical rather than food grade.
Applications
- Skin care formulations, where the stilbene structure provides antioxidant and antimicrobial activity
- Anti-ageing and protective cosmetics, used alongside resveratrol and pterostilbene in polyphenol blends
- Scalp and hair care preparations, formulated on the antifungal properties of the compound
- Oral care products, where pine stilbenes are used against plaque forming organisms
- Wood protection and coating formulations, using the natural durability role the compound plays in heartwood
- Analytical reference material for the assay of pine and knotwood extracts
- Research preparations in phytoalexin, plant defence and stilbene metabolism studies
China Manufacturers of Pinosylvin
Top Pinosylvin manufacturers in China.
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
Regulatory Status
Pinosylvin is not an authorised food ingredient in the major markets. In the United States it has no food additive regulation, no colour additive listing and no entry among substances generally recognised as safe, so food use would require a GRAS conclusion or a food additive petition that has not been established. Its practical regulatory home is cosmetics, which fall under the general safety provisions of the Federal Food, Drug, and Cosmetic Act without pre-market approval, and technical uses such as wood protection, where biocidal claims bring it under separate pesticide and biocide rules.
In the European Union pinosylvin has no E number and is not an authorised food additive. As a purified stilbene without a history of consumption before May 1997 it falls within the scope of Regulation 2015/2283 on novel foods, and no authorisation covering it has been granted, so it cannot be placed on the market as a food or supplement ingredient. Regulation 1223/2009 governs cosmetic use, and the substance is neither prohibited nor restricted, so it rests on a safety assessment held in the product information file, while antimicrobial claims for material protection fall under the Biocidal Products Regulation. Codex and JECFA have not evaluated the compound.
Manufacturing Process
The industrial feedstock is pine heartwood, bark and knotwood, most of it recovered as a residue from sawmilling and pulping. The wood is chipped and milled, then extracted with acetone, ethanol or an ethanol and water mixture at moderate temperature in a percolation battery, or with supercritical carbon dioxide modified with ethanol where a solvent free product is required. Knotwood is the preferred material because stilbene concentration there is far higher than in ordinary heartwood.
The crude extract is filtered and the solvent recovered under vacuum, leaving a resinous concentrate that also carries resin acids, lignans and fatty material. This concentrate is washed with a hydrocarbon solvent to remove the resin acid fraction, then treated with activated carbon and passed over a macroporous adsorption resin or a preparative chromatography column that separates pinosylvin from its monomethyl ether and from the accompanying lignans. The purified fraction is concentrated, recrystallised from an ethanol and water mixture, filtered on a centrifuge and dried under vacuum at low temperature in the dark. The dried crystals are milled, assayed by HPLC for total and trans content, and packed under nitrogen in light resistant containers. A fermentation route using engineered yeast or bacteria expressing stilbene synthase is also established at pilot scale.
