CAS 3458-28-4 · HS 29400090

D-Mannose

D-Mannose is a six-carbon aldohexose sugar and a C-2 epimer of glucose.

The CAS number is 3458-28-4 and the molecular formula is C₆H₁₂O₆ with a molar mass of 180.16 g/mol. The crystalline powder is white, freely water-soluble, and slightly less sweet than glucose.

D-Mannose is best known as a urinary tract health supplement. It is absorbed slowly from the gut, excreted largely unchanged in urine, and competes with bacterial adhesion proteins for binding sites on bladder epithelium, which is the mechanistic basis for its use in recurrent urinary tract infection prevention.

We source bulk D-Mannose from top China manufacturers for our partners, working with several of them. The manufacturers are in Jiangxi, Hebei and Henan. A smaller requirement can ship in a combined container with other ingredients.

Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.

or call +86-21-6858 0751

Packaging: 25 kg kraft paper bag with PE inner liner

ISO 9001
HACCP
Halal
Kosher

Specifications

Item	Specification
Appearance	White crystalline powder
Assay (HPLC, dry basis)	≥ 99.0%
Loss on drying	≤ 0.5%
Specific rotation	+13.5° to +15.0°
pH (10% solution)	5.0 to 7.0
Melting point	132 °C to 135 °C
Heavy metals (as Pb)	≤ 5 mg/kg
Arsenic	≤ 1 mg/kg
Residual solvents	Conforms to ICH Q3C
Total plate count	≤ 1,000 CFU/g

Common Markets Grades

There are three grades of D-Mannose: dietary supplement, pharmaceutical, and biotechnology research.

Supplement grade declares 98 to 99 percent purity and is a free-flowing white crystalline powder, often pre-sized for stick pack and capsule manufacture.

Pharmaceutical grade meets tighter limits on heavy metals and microbial counts and is used in registered medicinal products in some jurisdictions.

Glycobiology research grade runs at 99.5 percent or higher purity for use as a substrate or building block in glycoconjugate synthesis.

Both natural-source (from konjac glucomannan or wood mannan hydrolysis) and biotech-source (from glucose isomerisation) D-mannose are commercially available.

Applications

Active in urinary tract health supplements for recurrent infection prevention
Stick-pack and capsule supplements paired with cranberry and probiotic
Functional ingredient in womens health beverages and powders
Component of glycomic and glycobiology research substrates
Building block in oligosaccharide and glycoconjugate synthesis
Substrate in studies of mannose-binding lectins and immune signaling
Component of fucose-mannose blends in specialized supplements
Carbohydrate marker in glycoprotein analysis
Nutrient in cell culture media for mammalian cell lines
Reference compound in carbohydrate chromatography
Veterinary supplement for companion-animal urinary health

Brands Using D-Mannose

Widely-distributed consumer products that list D-Mannose on the ingredient label.

Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.

China Manufacturers of D-Mannose

Top D-Mannose manufacturers in China.

Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.

How We Help Source D-Mannose

Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your D-Mannose out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load D-Mannose together with other ingredients such as Fructooligosaccharides, Dextrose and Dextrose Monohydrate into one 20' FCL. If your quantity is small, we can also ship LCL.

Regulatory Status

D-Mannose is recognised as a food and dietary supplement ingredient in most major markets without an E number.

The U.S. FDA accepts D-mannose as a dietary supplement ingredient under DSHEA. It is permitted in foods and supplements in the European Union as a normal carbohydrate ingredient.

In some European countries D-mannose is registered as a medical device or pharmaceutical product specifically for urinary tract health.

Kosher and Halal certifications are routinely available from leading manufacturers.

Manufacturing Process

D-Mannose Manufacturing Process

Loading process diagram…

D-Mannose is produced from plant-source mannan-rich polysaccharides or from glucose by enzymatic isomerisation.

The plant route hydrolyses mannan-rich biomass such as ivory nut, konjac glucomannan, or coffee residue under mild acid or with mannanase enzymes to release free mannose. The hydrolysate is purified by carbon, ion exchange, and chromatographic separation from accompanying glucose.

The biotech route starts from glucose and uses cellobiose 2-epimerase or related enzymes to epimerize glucose to mannose. The reaction is followed by chromatographic separation of mannose from unreacted glucose.

The purified mannose solution is concentrated and crystallised. The crystals are washed, dried, and milled.