Acetyl Resveratrol
Acetyl resveratrol is resveratrol in which the three phenolic hydroxyl groups have been converted to acetate esters, giving 3,5,4'-triacetylresveratrol. It is a prodrug form: the ester groups are not stable in the body and are cleaved by esterases to release free resveratrol, so the ingredient is used to deliver resveratrol rather than for any activity of its own.
The reason for making it is that free resveratrol is chemically vulnerable. Its phenolic hydroxyls oxidise, it darkens in formulation, and the trans isomer converts to the less active cis form under ultraviolet light. Capping the hydroxyls removes the sites of oxidation and gives a molecule that is markedly more stable in cosmetic emulsions and in dry supplement blends, at the cost of being less water soluble than the parent.
The material is a white to off-white crystalline powder, practically insoluble in water and soluble in ethanol, ethyl acetate and oils, which suits it to anhydrous and oil-phase formulations. It is stable as a dry powder and tolerates normal processing temperatures, but the esters hydrolyse slowly in aqueous systems at alkaline pH, so formulations are held mildly acidic and the ingredient is added to the oil phase where possible.
We source bulk Acetyl Resveratrol from top China manufacturers for our partners. The manufacturer is in Zhejiang. A smaller requirement can ship in a combined container with other ingredients.
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- Function
- Plant extract
Specifications
| Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Assay (HPLC, dry basis) | 98.0 percent minimum as trans-triacetylresveratrol |
| Identification | Infrared spectrum and HPLC retention conform to reference standard |
| Free resveratrol | 0.5 percent maximum |
| Mono and diacetyl resveratrol | 1.0 percent maximum total |
| cis Isomer | 1.0 percent maximum |
| Melting point | 118 to 124 degrees C |
| Loss on drying | 0.5 percent maximum |
| Residue on ignition | 0.2 percent maximum |
| Residual solvents (ethanol) | 5000 mg/kg maximum |
| Residual solvents (pyridine) | 200 mg/kg maximum |
| Lead | 1.0 mg/kg maximum |
| Arsenic | 1.0 mg/kg maximum |
| Total plate count | 1000 cfu/g maximum |
Common Markets Grades
The compound is traded almost entirely as a single cosmetic and nutraceutical grade at 98 or 99 percent assay by HPLC, and the specification points that differentiate suppliers are the residual free resveratrol from incomplete acetylation, the partially acetylated mono and diacetyl species, and the trans to cis isomer ratio, since the trans form is the one that matters and ultraviolet exposure during processing shifts it.
Source is the second distinction. Resveratrol feedstock is either extracted from Polygonum cuspidatum root, which is the bulk route, produced by yeast fermentation, or made synthetically, and the acetylated product inherits the impurity profile of whichever was used, so a buyer wanting a natural or fermentation-derived declaration should specify it. Micronised grades with a stated particle size are used for dispersion, and solutions in cosmetic esters and glycols are offered for formulators who prefer a liquid.
Applications
- Anti-ageing serums and creams, where the acetylated form resists the browning that affects free resveratrol
- Skin brightening and antioxidant cosmetic formulations
- Sun care and after-sun products, where the ester form is more stable under light exposure
- Anhydrous oils, balms and facial oil blends
- Nutraceutical capsules and softgels positioned as a stabilised resveratrol delivery form
- Longevity supplement blends alongside nicotinamide riboside, fisetin and pterostilbene
- Colour cosmetics with skin-care positioning
- Hair and scalp treatments formulated on antioxidant claims
- Analytical reference standard for stilbene ester quantification
China Manufacturers of Acetyl Resveratrol
Top Acetyl Resveratrol manufacturers in China.
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
Regulatory Status
In the United States acetyl resveratrol is used principally as a cosmetic ingredient under the general safety and labelling provisions, which do not involve pre-market approval, and it appears in cosmetic ingredient listings under a name reflecting its triacetate structure. Where it is offered as a supplement ingredient it is a different substance from resveratrol itself, so a supplier should be able to document the basis on which it qualifies as a dietary ingredient rather than relying on the standing of the parent compound. Claims are structure and function claims with the standard disclaimer.
In the European Union it is regulated as a cosmetic ingredient under the cosmetic products regulation and is declared by its INCI name. For food use the position is more restrictive: trans-resveratrol itself required novel food authorisation, granted with specified conditions of use, and that authorisation does not extend to the acetylated derivative, which would need its own assessment. It carries no E number and is not an authorised food additive. Codex and JECFA have not adopted specifications for the compound.
Manufacturing Process
Manufacture starts from purified trans-resveratrol, which is itself obtained by extracting Polygonum cuspidatum root with aqueous ethanol, enriching over adsorption resin and recrystallising, or by fermentation or chemical synthesis. The resveratrol is dissolved in an aprotic solvent and acetylated with acetic anhydride in the presence of a base such as pyridine or a catalytic amount of dimethylaminopyridine, or with acetyl chloride under similar conditions. The reaction is run at moderate temperature and followed by chromatography until the triacetate is the dominant species, since stopping early leaves mono and diacetyl material behind.
Work-up quenches the excess anhydride, and the mixture is washed with dilute acid and then with dilute base to strip acetic acid and the amine catalyst, taking care not to hold the product in alkali because the new esters hydrolyse. The organic phase is dried, concentrated under vacuum, and the crude solid is recrystallised from ethanol or from an ethanol and water mixture, sometimes twice, to bring residual resveratrol and partial esters within specification. Crystals are washed, dried under vacuum at moderate temperature, milled and packed under nitrogen in light-excluding containers, since ultraviolet exposure isomerises the stilbene double bond.
