Choline Bitartrate
Choline Bitartrate is the L(+)-bitartrate salt of choline, the most widely used choline source in human dietary supplements and food fortification.
The molecule pairs the choline cation with L-tartaric acid in a one-to-one stoichiometry. Its molecular formula is C₉H₁₉NO₇ with a molar mass of 253.25 g/mol and CAS number 87-67-2. The salt delivers approximately 41 percent elemental choline.
We source bulk Choline Bitartrate from top China manufacturers for our partners, working with several of them. The manufacturers are in Shandong. For this ingredient the minimum order is 50 kg and a 20-foot container takes 9 MT, and a smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Minimum order
- 50 kg
- Qty in 20' FCL
- 9 MT
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Assay (dry basis) | 98.0% to 101.0% |
| Choline content | ≥ 41% |
| Loss on drying | ≤ 1.0% |
| pH (5% solution) | 3.0 to 5.0 |
| Heavy metals (as Pb) | ≤ 10 mg/kg |
| Arsenic | ≤ 3 mg/kg |
| Particle size | Per customer specification |
Common Markets Grades
Standard supplement-grade choline bitartrate is a white crystalline powder at 99 percent assay, packed in 25 kg fibre drums or kraft-paper bags with polyethylene liner.
Granular grades at 300 to 800 microns are produced for direct-compression tablets and capsule fills, where flow properties matter more than dissolution rate.
Fine-milled grades below 100 microns serve gummy bases, chewable tablets, and powdered drink mixes where rapid wet-out is required.
USP and Ph. Eur. grades meet pharmacopoeial monographs for identity, assay, optical rotation, heavy metals, and residual solvents. Both pharmacopoeias call out the L(+)-tartrate isomer specifically.
Kosher and Halal certifications are routine. Vegan and non-GMO documentation depends on the source of the upstream choline base, which is itself made from petrochemical feedstocks.
Applications
- Multivitamin and B-complex supplements as the choline source
- Prenatal supplements where choline supports fetal neural development
- Cognitive-health stacks blended with phosphatidylserine, citicoline, or huperzine A
- Sports-nutrition products targeting neuromuscular signaling
- Liver-support formulas built around choline and methyl donors
- Medical-food bars and powders for parenteral-to-enteral transition diets
- Infant nutrition fortification within applicable limits
- Powdered meal-replacement products and clinical-nutrition shakes
- Effervescent tablets and chewable wafers for pediatric and geriatric users
- Veterinary supplements for canine cognitive support and equine liver health
- Gummy and pastille formats where the slight tartness improves taste masking
Brands Using Choline Bitartrate
Widely-distributed consumer products that list Choline Bitartrate on the ingredient label.
- NOW FoodsCholine 300 mg Veg Capsules ↗NOW Foods Choline veg capsules supply 300 mg of choline (as choline bitartrate), a component of phosphatidylcholine and a precursor to the neurotransmitter acetylcholine.Label verified 2026-05-24
- NOW FoodsCholine & Inositol 500 mg Veg Capsules ↗NOW Foods Choline & Inositol capsule combines 250 mg choline bitartrate and 250 mg inositol per capsule for brain and lipid metabolism support.Label verified 2026-05-24
- Source NaturalsInositol & Choline Tablets ↗Source Naturals Inositol & Choline tablet supplies choline bitartrate together with inositol as members of the B-complex involved in fat metabolism and acetylcholine synthesis.Label verified 2026-05-24
- SolgarCholine 350 mg Vegetable Capsules ↗A vegetable capsule supplying 350 mg choline as choline bitartrate.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Choline Bitartrate
Top Choline Bitartrate manufacturers in China.
- Jinan Asia Pharmaceutical Co., Ltd.9 ingredients in the directory
Jinan Pengbo Biotechnology Co., Ltd.9 ingredients in the directory
Shandong Aobo Bio-Tech Co., Ltd.11 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Choline Bitartrate
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Choline Bitartrate out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Choline Bitartrate together with other ingredients such as Arachidonic Acid, Coenzyme Q10 and Chondroitin Sulphate Sodium into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Choline Bitartrate is permitted as a nutrient source in food and dietary supplements in virtually every regulated market.
The U.S. Food and Drug Administration recognises choline bitartrate as GRAS for use as a nutrient source in conventional foods, infant formula, and dietary supplements. Choline carries an Adequate Intake reference value in U.S. dietary guidance.
The European Union lists choline bitartrate among the approved choline sources for food supplements in Annex II of Directive 2002/46/EC and for infant formula and follow-on formula in Commission Delegated Regulation (EU) 2016/127.
Pharmacopoeial monographs for Choline Bitartrate appear in the United States Pharmacopeia (USP) and the European Pharmacopoeia (Ph. Eur.). The Japanese Standards of Food Additives also list the salt.
Halal, Kosher, and non-GMO certifications are routinely available, although the synthetic origin of choline means vegan claims require documentation of the upstream catalysts and processing aids.
Manufacturing Process
Choline bitartrate is manufactured by neutralising choline base, choline hydroxide, or choline chloride with L(+)-tartaric acid in aqueous solution.
The starting choline is produced industrially from the reaction of trimethylamine with ethylene oxide in the presence of water, a route operated at scale by Eastman, BASF, and several Chinese producers. The choline intermediate is produced either as the chloride salt or as an aqueous hydroxide solution.
The neutralisation is carried out under controlled pH and temperature to give an equimolar bitartrate salt. The solution is concentrated under vacuum and cooled to crystallise the product. Crystals are centrifuged, washed with cold water or dilute ethanol, and dried in a fluid bed.
Particle size is adjusted by classifying mills or by tuning the cooling profile of the crystalliser. The final powder is screened, blended for assay uniformity, and packed under controlled humidity, since the salt is mildly hygroscopic.
Quality testing covers choline content, tartrate content, optical rotation, water, and residual solvents.
