Chondroitin Sulphate
Chondroitin Sulphate is a sulfated glycosaminoglycan (GAG) built from repeating disaccharide units of D-glucuronic acid and N-acetylgalactosamine, with sulphate groups at the 4- or 6-position of the galactosamine residue.
It is one of the principal structural components of cartilage, bone, skin, and the vascular wall. The polymer is produced commercially as a free acid or, more commonly, as the sodium salt under CAS number 9007-28-7.
We source bulk Chondroitin Sulphate from top China manufacturers for our partners, working with several of them. The manufacturers are mostly in Hubei, Shandong and Sichuan. For this ingredient the minimum order is 25 kg and a 20-foot container takes 9 MT, and a smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Minimum order
- 25 kg
- Qty in 20' FCL
- 9 MT
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | White to almost white powder |
| Identification (IR and HPLC) | Conforms |
| Assay (CPC titration, dried basis) | ≥ 90.0% |
| Specific Rotation (40 mg/mL) | -25° to -32° |
| Nitrogen (dried basis) | 2.5 - 3.5% |
| pH (5% solution) | 6.0 - 7.0 |
| Loss on Drying (105°C, 4 h) | ≤ 10.0% |
| Residue on Ignition (dried basis) | 20.0 - 30.0% |
| Chloride | ≤ 0.5% |
| Sulphate | ≤ 0.24% |
| Protein | ≤ 6.0% |
| Heavy Metals (as Pb) | ≤ 20 mg/kg |
| Total Plate Count | ≤ 1,000 cfu/g |
| Yeast and Mould | ≤ 100 cfu/g |
| Salmonella | Negative/25g |
Common Markets Grades
Chondroitin sulphate is graded by purity, molecular weight, and source documentation.
Pharmaceutical-grade material at 95 to 99 percent assay (CPC titration) meets USP and Ph. Eur. monographs and is produced for prescription osteoarthritis products in several EU countries and for injectable veterinary medicines.
Supplement-grade material at 90 percent assay is the standard grade for joint-health capsules and tablets, often co-blended with glucosamine and MSM.
Cosmetic-grade material at 85 to 90 percent assay is produced for hydrating serums and ophthalmic formulations.
Molecular weight ranges from about 10 kDa to 50 kDa depending on the source tissue and processing conditions. Source claims of bovine, porcine, avian (chicken sternum), or marine (shark cartilage, fish nasal cartilage) origin are documented on the certificate for allergen and dietary declarations downstream.
Applications
- Joint-health supplements, typically paired with glucosamine sulphate or hydrochloride
- Triple-combination capsules with glucosamine and MSM at 1200 mg chondroitin per daily dose
- Prescription osteoarthritis products in the EU (SYSADOA category) at 800 to 1200 mg per day
- Veterinary injectable products for equine and canine joint disease
- Topical creams and gels for localized joint pain
- Ophthalmic eye drops for dry-eye relief and corneal surface protection
- Surgical viscoelastic solutions used in cataract and intraocular procedures
- Cosmetic anti-aging serums and post-procedure repair creams
- Wound-care dressings and biomaterial scaffolds
- Sports-recovery formulas targeting connective-tissue resilience
- Pet supplements for senior dogs, cats, and horses
Brands Using Chondroitin Sulphate
Widely-distributed consumer products that list Chondroitin Sulphate on the ingredient label.
- Osteo Bi-FlexTriple Strength Glucosamine Chondroitin ↗Combines glucosamine HCl with chondroitin sulphate and MSM, plus 5-LOXIN Advanced boswellia, in a joint formula.Label verified 2026-05-24
- Cosamin (Nutramax)Cosamin DS Joint Health Supplement ↗Cosamin DS by Nutramax delivers 1,500 mg glucosamine HCl (FCHG49) plus 1,200 mg chondroitin sulphate (TRH122) per serving, the clinically researched joint-comfort blend.Label verified 2026-05-24
- NOW FoodsChondroitin Sulfate 600 mg Capsules ↗NOW Foods Chondroitin Sulfate 600 mg supplies chondroitin sulphate sourced from bovine cartilage as a glycosaminoglycan that supports joint cartilage, lubrication and mobility.Label verified 2026-05-24
- ThorneGlucosamine & Chondroitin Capsules ↗Capsules combining 500 mg glucosamine sulphate with 250 mg bovine chondroitin sulphate per capsule.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Chondroitin Sulphate
Top Chondroitin Sulphate manufacturers in China.
Hubei Huge Collagen Ii Biotechnology Co., Ltd.5 ingredients in the directory
Meitek (Qingdao) Co., Ltd.13 ingredients in the directory
Sichuan Huigukang Biotechnology Co., Ltd.3 ingredients in the directory
Tianxian Biopharm4 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Chondroitin Sulphate
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Chondroitin Sulphate out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Chondroitin Sulphate together with other ingredients such as Arachidonic Acid, Coenzyme Q10 and Chondroitin Sulphate Sodium into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Chondroitin Sulphate is regulated as a dietary supplement, a prescription drug, or a medical-device component depending on the jurisdiction and use.
The U.S. Food and Drug Administration accepts chondroitin sulphate as a dietary ingredient under DSHEA. Major NIH-funded trials (GAIT) have studied its efficacy in knee osteoarthritis.
The European Medicines Agency authorises chondroitin sulphate as a prescription medicine for the symptomatic treatment of osteoarthritis in several member states, with both food-supplement and pharmacy channels active.
Pharmacopoeial monographs for Chondroitin Sulphate Sodium appear in the United States Pharmacopeia (USP), the European Pharmacopoeia (Ph. Eur.), and the Japanese Pharmacopoeia (JP). The monographs specify assay, identification, molecular-weight distribution, and species-of-origin testing.
Bovine source material is subject to TSE/BSE risk evaluation under EMA and FDA guidance. Marine source material must address country of origin and sustainability claims, particularly for shark cartilage.
Manufacturing Process
Industrial chondroitin sulphate is extracted from animal cartilage rather than synthesised.
Bovine tracheal cartilage, porcine nasal septum, chicken keel and sternum cartilage, and shark cartilage are the principal feedstocks. The raw material is washed, defatted, and digested with proteolytic enzymes such as papain or alcalase to release the GAG chains from the proteoglycan core protein.
The crude extract is filtered, treated with activated carbon, and the GAGs are precipitated with ethanol or quaternary ammonium reagents. Ion-exchange chromatography removes other GAGs (notably keratan sulphate and hyaluronic acid), and a second precipitation gives the purified chondroitin sulphate.
The wet cake is dissolved in water, neutralised to give the sodium salt (or kept as the free acid for niche use), spray-dried, and milled. Final material is tested for assay, molecular weight by HPLC-SEC, sulphate ratio, and species identification by PCR or electrophoresis.
A small but growing fermentation route produces non-animal chondroitin sulphate via engineered Escherichia coli, but volumes remain limited.
