Neohesperidin Dihydrochalcone
Neohesperidin Dihydrochalcone is a semi-synthetic, high-intensity sweetener derived from neohesperidin, a bitter flavanone glycoside abundant in the peel of bitter (Seville) oranges. Catalytic hydrogenation opens the flavanone C-ring to give the corresponding dihydrochalcone, which is intensely sweet rather than bitter.
The molecule has the formula C₂₈H₃₆O₁₅ and a molar mass of 612.58 g/mol. It is an off-white to pale yellow crystalline powder, sparingly soluble in cold water and freely soluble in hot water, ethanol, and dilute alkaline solutions. Commonly abbreviated NHDC, the compound delivers a sweetness intensity of 1,500 to 1,800 times that of sucrose at typical use levels.
The sweetness profile is slow-onset and long-lasting, with a characteristic licorice and cooling menthol-like aftertaste that becomes more pronounced at higher concentrations. The distinctive finish makes NHDC most useful as a flavour enhancer, masking agent, and co-sweetener rather than as a standalone primary sweetener.
We source bulk Neohesperidin Dihydrochalcone from top China manufacturers for our partners, working with several of them. The manufacturers are mostly in Sichuan, Hunan and Zhejiang. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Assay (NHDC) | ≥ 96.0% |
| Loss on Drying | ≤ 11.0% |
| Residue on Ignition | ≤ 0.2% |
| Specific Rotation | -46° to -52° |
| Heavy Metals (as Pb) | ≤ 10 ppm |
| Arsenic | ≤ 3 ppm |
| Sweetness | 1500-1800 times sweeter than sucrose |
| Solubility | 0.5 g/L at 25°C |
Common Markets Grades
There is one grade of neohesperidin dihydrochalcone, at 96 percent minimum assay on the dried basis, serving both food and pharmaceutical use. It comes in different particle sizes and as carrier dilutions, which are physical forms of the same grade rather than separate grades.
The standard physical form is a fine to medium crystalline powder. A micronized form is produced for chewing gum and oral-care formulations where small particle size aids dispersion and slow release.
Because NHDC is most commonly used in synergistic combination with other intense sweeteners, working dilutions on maltodextrin or dextrose carriers are sometimes prepared to ease accurate batch dosing at the low use levels involved. The food-grade material complies with the FCC monograph.
Applications
- Bitter-masking agent for high-intensity sweeteners such as saccharin and acesulfame potassium
- Flavour enhancement and sweetness rounding in diet and reduced-sugar carbonated soft drinks
- Sugar-free chewing gum and breath mints, where the long-lasting sweetness extends flavour perception
- Hard candies, throat lozenges, and cough drops
- Pharmaceutical chewable tablets, lozenges, and oral suspensions for masking bitter actives
- Toothpaste, mouthwash, and other oral-care products
- Animal feed and pet treats as a palatability enhancer and bitter-masker for medicated feed
- Bitter-masking in protein powders, amino-acid supplements, and meal-replacement shakes
- Reduced-sugar fruit beverages and citrus-flavoured drinks
- Sauces, dressings, and condiments where sweetness rounding is desired
- Cosmetic flavoured lip products and lip balms
- Salt-reduction product formulations as a sensory rounding agent
China Manufacturers of Neohesperidin Dihydrochalcone
Top Neohesperidin Dihydrochalcone manufacturers in China.
Chengdu Okay Pharmaceutical Co., Ltd.7 ingredients in the directory
Lianyuan Kang Biotech. Co., Ltd.7 ingredients in the directory
Ningbo Herb Pharma Corp.7 ingredients in the directory
Shandong Benyue Biological Technology Co., Ltd.5 ingredients in the directory
WuHan HuaSweet Co., Ltd.6 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Neohesperidin Dihydrochalcone
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Neohesperidin Dihydrochalcone out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Neohesperidin Dihydrochalcone together with other ingredients such as Stevia, Erythritol and Maltitol into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Neohesperidin dihydrochalcone is approved as a food additive in the European Union and a number of other markets, with more limited approval status in the United States.
In the European Union it carries the E number E959 under Regulation (EC) No 1333/2008, both as a sweetener and as a flavour enhancer, with use levels defined per food category in Annex II.
The U.S. Food and Drug Administration does not list NHDC under the general-purpose intense-sweetener provisions. The substance has been the subject of GRAS notifications in the United States for use as a flavour and flavour enhancer in specific food categories.
JECFA has evaluated neohesperidin dihydrochalcone and assigned acceptable status as a sweetener and flavour enhancer. Health Canada and several Asian and Latin American regulators permit its use under defined conditions. Halal and Kosher certifications are commonly available because the manufacturing process uses no animal-derived inputs.
Manufacturing Process
Neohesperidin dihydrochalcone is produced from neohesperidin, a flavanone glycoside that occurs at percent-level concentrations in the immature peel of bitter (Seville) orange, Citrus aurantium.
Bitter orange peel is extracted with hot water or aqueous ethanol, and neohesperidin is recovered from the extract by precipitation, crystallisation, or column chromatography. An alternative starting point is naringin, which is first converted to neohesperidin by methylation in some industrial routes.
The purified neohesperidin is dissolved in dilute alkaline solution to open the flavanone C-ring to the corresponding chalcone, which is then catalytically hydrogenated over a palladium-on-carbon catalyst under hydrogen pressure. The hydrogenation reduces the α,β-unsaturated ketone of the chalcone to give the dihydrochalcone, in which the sweet taste is established.
The crude dihydrochalcone is neutralised, decolorised with activated carbon, and crystallised from water or aqueous ethanol. The dried crystals are milled to the target particle size, screened, and packaged.
