Calcium Gluconate
Calcium Gluconate is the calcium salt of gluconic acid, with the formula Ca(C₆H₁₁O₇)₂ (CAS 299-28-5). It delivers approximately 9 percent elemental calcium, the lowest of the common pharmaceutical calcium salts, but in exchange dissolves readily in water and is well tolerated in the gut.
The salt is the standard parenteral calcium source in hospital practice and is also used as an oral supplement, food fortificant, and topical antidote for hydrofluoric acid burns.
We source bulk Calcium Gluconate from top China manufacturers for our partners, working with several of them. The manufacturers are in Shandong, Zhejiang and Jiangsu. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
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- Packaging
- 25 kg kraft paper bag with PE inner liner
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | White crystalline granules or powder |
| Odour | Odourless, tasteless |
| Identification | Conforms to USP / FCC |
| Assay (dried basis) | 98.0 - 102.0% |
| Calcium (as Ca) | 8.9 - 9.3% |
| Loss on Drying | ≤ 1.0% |
| pH (5% solution) | 6.0 - 8.0 |
| Reducing Substances | ≤ 1.0% |
| Magnesium and Alkali Metals | ≤ 0.4% |
| Chloride | ≤ 50 mg/kg |
| Sulfate | ≤ 50 mg/kg |
| Sulfated Ash | ≤ 0.05% |
| Heavy Metals (as Pb) | ≤ 20 mg/kg |
| Arsenic | ≤ 3 mg/kg |
| Total Plate Count | ≤ 1,000 cfu/g |
Common Markets Grades
Calcium Gluconate is produced primarily as the monohydrate.
USP-grade powder is the dominant pharmaceutical specification, used for sterile injectable manufacture and oral solid dosage formulation. The injectable raw material undergoes additional endotoxin testing and is dissolved into 10 percent w/v sterile solutions for intravenous administration.
Food Chemicals Codex grade covers calcium fortification, acidity regulation, and firming applications. Granular grades support direct compression of tablets and effervescent calcium products.
Topical-formulation grade is produced for the manufacture of 2.5 percent gels used as a first-aid antidote for skin exposure to hydrofluoric acid.
Applications
- Intravenous calcium for symptomatic hypocalcemia, calcium-channel blocker overdose, and magnesium toxicity
- Cardiac protection in acute hyperkalemia by stabilising the cardiac membrane potential
- Topical 2.5 percent gel for first-aid treatment of hydrofluoric acid burns
- Oral calcium supplements in tablet, effervescent, and syrup formats
- Pediatric calcium syrups and chewable preparations for growing children
- Calcium fortification of beverages, isotonic sports drinks, and nutritional waters
- Firming agent in canned fruits and vegetables to preserve texture during processing
- Sequestrant and acidity regulator in low-sugar jams and dairy desserts
- Tablet binder and disintegration aid in compressed pharmaceutical dosage forms
- Calcium source in clinical and enteral nutrition formulas
- Veterinary injectable for milk fever (parturient paresis) in dairy cattle
Brands Using Calcium Gluconate
Widely-distributed consumer products that list Calcium Gluconate on the ingredient label.
- Fresenius KabiCalcium Gluconate Injection, USP 10% ↗FDA-approved Calcium Gluconate Injection, USP 10% labeling: 100 mg calcium gluconate per mL (9.3 mg elemental Ca per mL) for IV use in hypocalcemia and other indications; presented in 10/50/100 mL vials. Manufactured under FDA NDA 208418.Label verified 2026-05-24
- Empower PharmacyCalcium Gluconate Injection (compounded) ↗Empower Pharmacy compounded calcium gluconate injection (sterile injectable) listed on its compounding pharmacy site for medical use.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of Calcium Gluconate
Top Calcium Gluconate manufacturers in China.
Jiangsu Huanyu Kangli Technology Co., Ltd.3 ingredients in the directory
Penglai Marine (Shandong) Co., Ltd.10 ingredients in the directory
Shandong Xinhong Pharmaceutical Co., Ltd.9 ingredients in the directory
Shandong Zhongxing Food Technology Co., Ltd.8 ingredients in the directory- Zhejiang Ruibang Laboratories4 ingredients in the directory
Zhejiang Tianyi Food Additives Co., Ltd.10 ingredients in the directory
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source Calcium Gluconate
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Calcium Gluconate out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Calcium Gluconate together with other ingredients such as Sodium Acetate, Calcium Citrate and Sodium Lactate into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
Calcium Gluconate is approved in food, supplement, and pharmaceutical channels worldwide.
In the European Union it is listed as food additive E578, permitted as an acidity regulator, sequestrant, and firming agent. It is also approved as a calcium source for food supplements and fortified foods.
The U.S. Food and Drug Administration affirms it as GRAS under 21 CFR 184.1199 for general food use. Pharmacopoeial monographs appear in USP-NF, Ph. Eur., BP, and JP, with separate monographs covering Calcium Gluconate Injection and Calcium Gluconate Tablets.
The World Health Organisation includes Calcium Gluconate on the WHO Model List of Essential Medicines for the treatment of hypocalcemia and as an antidote for fluoride and oxalate poisoning.
Manufacturing Process
Calcium Gluconate is manufactured by neutralisation of gluconic acid with a calcium source.
Industrial gluconic acid is produced by submerged aerobic fermentation of glucose using Aspergillus niger or, increasingly, Gluconobacter species. The microbial enzyme glucose oxidase converts glucose to gluconic acid with high selectivity and yield.
The fermentation broth is clarified, then neutralised with calcium carbonate or calcium hydroxide. The resulting Calcium Gluconate is crystallised from the cooled solution, recovered, washed, and dried as the monohydrate.
Pharmaceutical-grade material requires additional decolorisation with activated carbon, ion-exchange polishing, and recrystallisation to meet pharmacopoeial purity for parenteral use. Injectable solutions are sterile-filtered and terminally sterilised after fill.
