L-Alpha-GPC
L-Alpha-GPC is L-α-glycerylphosphorylcholine (C₈H₂₀NO₆P, CAS 28319-77-9), a water-soluble choline-containing phospholipid metabolite.
It is one of the most bioavailable forms of dietary choline and crosses the blood-brain barrier intact, where it serves as both a substrate for acetylcholine synthesis and a structural precursor for membrane phosphatidylcholine.
We source bulk L-Alpha-GPC from top China manufacturers for our partners. The manufacturer is in Shandong. A smaller requirement can ship in a combined container with other ingredients.
Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.
or call +86-21-6858 0751
- Packaging
- 250 kg plastic drum or 1,000 kg IBC tote
- ISO 9001
- HACCP
- Halal
- Kosher
Specifications
| Item | Specification |
|---|---|
| Appearance | White to off-white hygroscopic powder (50% grade); free-flowing powder (85% grade) |
| Identification (HPLC and NMR) | Conforms to reference standard |
| Assay (L-α-Glycerylphosphorylcholine, HPLC) | ≥ 50.0% (silica-dispersed grade) or ≥ 85.0% (concentrated grade) |
| Choline Content (calculated on Alpha-GPC) | ≥ 40.0% |
| Specific Rotation [α]D²⁰ | -2.0° to -4.0° (c = 5, water) |
| Water (Karl Fischer) | ≤ 5.0% (50% grade); ≤ 12.0% (85% grade) |
| Free Choline | ≤ 1.0% |
| Carrier (Silicon Dioxide, 50% grade) | 45.0 – 50.0% |
| pH (10% aqueous solution) | 5.0 – 8.0 |
| Residual Solvent (Ethanol) | ≤ 0.5% |
| Heavy Metals (as Pb) | ≤ 10 mg/kg |
| Arsenic (as As) | ≤ 1 mg/kg |
| Total Plate Count | ≤ 1,000 cfu/g |
| Yeast and Mould | ≤ 100 cfu/g |
| Pathogens (E. coli, Salmonella) | Negative/25g |
Common Markets Grades
L-Alpha-GPC is graded by assay strength of choline glycerophosphate.
The 50 percent grade is a hygroscopic powder dispersed on silicon dioxide, calcium silicate, or maltodextrin to make it workable in tabletting and capsule filling. The 85 percent grade is a more concentrated free-flowing powder for high-dose nootropic capsules and stick packs.
The 99 percent grade is a sticky semi-solid sold in jars or drums for injectable and prescription formulations, primarily in Italy and Eastern Europe where alpha-GPC is registered as a medicinal product. A 99 percent solution in water or propylene glycol is also offered for liquid supplements.
Branded grades such as AlphaSize from Chemi Nutra carry batch-level documentation of source, purity, and absence of soy and gluten contaminants.
Applications
- Nootropic capsules and tablets for memory, focus, and mental clarity
- Pre-workout formulations targeting mind-muscle connection and power output
- Brain-health supplements aimed at aging, often combined with citicoline or huperzine A
- Sports nutrition stacks for growth-hormone modulation claims
- Cognitive support formulations for students and shift workers
- Medical foods and clinical nutrition for cognitive decline in some jurisdictions
- Prescription pharmaceuticals for stroke recovery and dementia in Italy, Russia, and South Korea
- Functional gummies, shots, and ready-to-drink cognitive beverages
- Veterinary cognitive support for senior dogs
- Research reagent in cholinergic neuroscience studies
Brands Using L-Alpha-GPC
Widely-distributed consumer products that list L-Alpha-GPC on the ingredient label.
- OnnitAlpha BRAIN Capsules ↗Alpha BRAIN nootropic capsules feature Alpha-GPC (L-alpha-glycerylphosphorylcholine) as a key choline-donor ingredient supporting acetylcholine synthesis for memory and focus.Label verified 2026-05-24
- Designs for HealthGPC Liquid ↗A liquid supplying 600 mg L-alpha-glycerylphosphorylcholine (as CholineAid) per serving.Label verified 2026-05-24
- Jarrow FormulasAlpha GPC 300 mg Veggie Capsules ↗300 mg L-alpha-glycerylphosphorylcholine per veggie capsule.Label verified 2026-05-24
- NOW FoodsAlpha GPC 300 mg Veg Capsules ↗NOW Foods Alpha GPC capsule supplies 300 mg of Alpha-glycerylphosphorylcholine for cognitive health support.Label verified 2026-05-24
Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.
China Manufacturers of L-Alpha-GPC
Top L-Alpha-GPC manufacturers in China.
Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.
How We Help Source L-Alpha-GPC
Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your L-Alpha-GPC out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load L-Alpha-GPC together with other ingredients such as Arachidonic Acid, Coenzyme Q10 and Chondroitin Sulphate Sodium into one 20' FCL. If your quantity is small, we can also ship LCL.
Regulatory Status
L-Alpha-GPC has a split regulatory profile across major markets.
In the United States it is a lawful dietary supplement ingredient under DSHEA, with NDI notifications on file. In Canada it is listed as a Natural Health Product ingredient for cognitive support. In the European Union it is sold as a food supplement at typical doses of 300 to 600 mg per day, although Italy continues to register it as a prescription medicine under the trade name Gliatilin.
It carries pharmaceutical authorisation for cognitive disorders in Russia, South Korea, and several Eastern European markets. Japan permits it as a food with function claims under specific notification.
The substance is not on the WADA prohibited list. Soy-source GPC must declare soy as an allergen on label in most markets, while sunflower-source GPC is allergen-free.
Manufacturing Process
L-Alpha-GPC is manufactured by enzymatic or chemical deacylation of purified phosphatidylcholine.
The starting material is high-grade soy lecithin or, increasingly, sunflower lecithin for soy-free positioning. The lecithin is fractionated to enrich phosphatidylcholine to 50 percent or higher, then treated with phospholipase A₁ and A₂ or with alkaline methanolysis to cleave the two fatty acid chains and release alpha-GPC together with the fatty acid methyl esters.
The crude alpha-GPC is separated from glycerol, salts, and residual lipids by ion-exchange chromatography or membrane filtration. The purified material is then either spray-dried directly with a carrier or further concentrated to the 85 percent or 99 percent grade.
Process control focuses on residual solvents, fatty acid esters, and microbiological limits. Production is concentrated in Italy, China, and Japan, with Chemi Nutra of the United States and several Korean houses operating the largest dedicated GPC plants.
