CAS 778571-57-6 · HS 29181990

Magnesium L-Threonate

Magnesium L-Threonate is the magnesium salt of L-threonic acid, a four-carbon sugar acid derived from vitamin C metabolism.

The compound carries CAS number 778571-57-6 and is produced almost exclusively under the trademark Magtein, originally developed at the Massachusetts Institute of Technology and commercialized by AIDP with Nature's Bounty as a downstream brand partner. It is positioned as the cognitive magnesium, with clinical work pointing to brain-tissue magnesium loading after oral dosing.

We source bulk Magnesium L-Threonate from top China manufacturers for our partners, working with several of them. The manufacturers are in Shandong and Hebei. A smaller requirement can ship in a combined container with other ingredients.

Please send the grade you need, the volume and your destination port, and we will come back with a solution and a price.

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Packaging: 25 kg kraft paper bag with PE inner liner

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Specifications

Item	Specification
Appearance	White to off-white free-flowing powder
Assay (dry basis)	≥ 98.0%
Elemental magnesium	8.0 to 9.0% w/w
L-threonic acid content	72 to 78% w/w
L-threonate isomeric purity	≥ 99% L-form
Loss on drying	≤ 5.0%
Heavy metals (as Pb)	≤ 3 mg/kg
Arsenic	≤ 1 mg/kg
Cadmium	≤ 1 mg/kg
Mercury	≤ 0.1 mg/kg
Total plate count	≤ 1000 CFU/g
Salmonella	Absent in 25 g
Shelf life	24 months from manufacture under recommended storage
Storage	Cool, dry, sealed

Common Markets Grades

The commercial supply chain is narrow, centred on the patented Magtein material.

Magtein delivers approximately 8 percent elemental magnesium, the lowest of any common magnesium supplement form. The trade-off is intentional, since the threonate carrier is held to be the active vehicle for blood-brain barrier transit.

The standard grade is a free-flowing white-to-off-white powder meeting USP-style limits for heavy metals, residual solvents, and microbiological purity. Particle size is tuned for capsule and stick-pack filling rather than direct tablet compression.

Generic non-Magtein magnesium L-threonate has appeared from Indian and Chinese manufacturers in recent years, typically at lower price points but without the clinical-trial dossier or the brand recognition that supports finished-product premium pricing.

Applications

Cognitive-support supplements positioned around memory, learning, and focus
Healthy-aging brain formulas paired with phosphatidylserine, citicoline, or omega-3 DHA
Sleep formulas where deeper slow-wave sleep is the marketing claim
Stress and anxiety blends combining magnesium with L-theanine and adaptogens
Nootropic stacks for students, knowledge workers, and biohackers
Senior multivitamins targeting cognitive resilience
Specialty practitioner-channel products for neurology and integrative-medicine clinics
Premium sleep-and-recovery powders in stick-pack or ready-to-mix formats

Brands Using Magnesium L-Threonate

Widely-distributed consumer products that list Magnesium L-Threonate on the ingredient label.

Brand names, product names and logos are the property of their owners. They appear here as published evidence that the ingredient is used, taken from the brand's own label or website. Their appearance is not an endorsement, and it does not mean the brand buys from us or from any manufacturer listed on this site.

China Manufacturers of Magnesium L-Threonate

Top Magnesium L-Threonate manufacturers in China.

Company names and logos are the property of the manufacturers themselves. They are listed here because our own directory records them as producing this ingredient. A listing is not an endorsement by them, and we do not represent them or speak on their behalf.

How We Help Source Magnesium L-Threonate

Direct Factory Sourcing
We run the whole process: selecting the manufacturer from the top Chinese food ingredient producers, negotiating the price, verifying quality, and coordinating the logistics. You deal with us instead of with several factories at once.
Original Packaging and Documents from the Manufacturer
The manufacturer sends your Magnesium L-Threonate out of its own factory in the original packing, through to your destination port. The COA, COO, MSDS, TDS and any certifications reach you from the manufacturer as well.
Free Samples and Lead Time
We send 100 to 500 g free for your own laboratory to test and you cover only the courier, usually within 2 to 3 working days. ETD is usually within 7 to 15 days once the order is confirmed, and we check that date against the factory's own manufacturing schedule before we give it to you.
Combined Shipment
We can load Magnesium L-Threonate together with other ingredients such as Sodium Acetate, Calcium Citrate and Sodium Lactate into one 20' FCL. If your quantity is small, we can also ship LCL.

Regulatory Status

Magnesium L-Threonate has cleared the relevant safety reviews for dietary-supplement use.

In the United States, AIDP filed a New Dietary Ingredient notification with the FDA in 2010, and Magtein subsequently received self-affirmed GRAS status for use in food and beverage products.

The European authorisation picture is more limited. Magnesium L-Threonate is not currently listed in Annex II of Directive 2002/46/EC, which restricts its use as a magnesium source in EU food supplements. Sales channels in the EU therefore route through novel food review or non-supplement formats.

Patent protection through the Magtein portfolio remains a key regulatory and commercial gatekeeper, with infringement actions taken against unlicensed cognitive-positioned imitators.

Manufacturing Process

Magnesium L-Threonate Manufacturing Process

Loading process diagram…

The manufacturing route begins with L-ascorbic acid (vitamin C) as the starting material.

Controlled oxidative cleavage of L-ascorbic acid, typically with hydrogen peroxide under alkaline conditions, opens the lactone ring and yields L-threonic acid alongside oxalic acid. The two acids are separated by ion-exchange chromatography or selective crystallisation.

Purified L-threonic acid is then neutralised with magnesium carbonate or magnesium hydroxide in aqueous solution. The reaction produces magnesium L-threonate in a 1 to 2 magnesium to threonate ratio with evolution of carbon dioxide or water.

The resulting solution is concentrated, spray-dried or freeze-dried, and milled to specification. Strict control over residual oxalate, peroxide, and starting-material impurities is required, as these can affect both safety and clinical performance.

AIDP holds the supply rights for Magtein through licensing arrangements that originated with the MIT research team led by Guosong Liu. The patent portfolio covers both the composition of matter and the cognitive use claims.